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Database: UniProt
Entry: A0A3B3TMK6_9TELE
LinkDB: A0A3B3TMK6_9TELE
Original site: A0A3B3TMK6_9TELE 
ID   A0A3B3TMK6_9TELE        Unreviewed;      1030 AA.
AC   A0A3B3TMK6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE            EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN   Name=SSH1 {ECO:0000313|Ensembl:ENSPLAP00000001526.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000001526.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000001526.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001482};
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       {ECO:0000256|ARBA:ARBA00009580}.
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DR   RefSeq; XP_014874185.1; XM_015018699.1.
DR   AlphaFoldDB; A0A3B3TMK6; -.
DR   STRING; 48699.ENSPLAP00000001526; -.
DR   Ensembl; ENSPLAT00000014589.1; ENSPLAP00000001526.1; ENSPLAG00000002603.1.
DR   GeneID; 106937273; -.
DR   KEGG; plai:106937273; -.
DR   CTD; 101885659; -.
DR   GeneTree; ENSGT00940000156133; -.
DR   OrthoDB; 5490735at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR   CDD; cd11652; SSH-N; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR014876; DEK_C.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR043587; Phosphatase_SSH-like.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR043588; SSH-N.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   PANTHER; PTHR45864:SF5; PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 1; 1.
DR   PANTHER; PTHR45864; SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG; 1.
DR   Pfam; PF08766; DEK_C; 1.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF109715; DEK C-terminal domain; 1.
DR   PROSITE; PS51998; DEK_C; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912}.
FT   DOMAIN          251..306
FT                   /note="DEK-C"
FT                   /evidence="ECO:0000259|PROSITE:PS51998"
FT   DOMAIN          310..451
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50054"
FT   DOMAIN          372..429
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          699..745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          907..934
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          994..1030
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..927
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1002..1016
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  113254 MW;  CF16FAD1B9CA6C15 CRC64;
     MALVTLQRSP TPSAASTAST ATTTAGEDFG SDDERRINQS LSESFFMVKG AALFLQQGSS
     QQGQKAHPPH KHAGELPQHL QVMINILRSE DRIKLAVRLE SAWSDRVRYM VVVYTSGRQD
     TEENILLGID FTNKDCKSCS IGMVLPLWSD TKIHLDGDGG FTVNTAGRTH VFKPVSVQAM
     WSALQVLHKA CEVSRRFNYF PGGMALTWMG YYESCIASEQ SCINEWNAMK DLETTRPDSP
     IMFVDKPSER ERTECLIKSK LRSIMTSQDL ENVTCKQIRT KLEQHMNCNL KEYKEFIDNE
     MLLILGQMDK ATLIFDHVYL GSEWNASNLE ELQETGVGYI LNVTREIDNF FPGTFCYHNI
     RVYDEDATDL LAHWNNTYNF IMKAKKNDSK CLVHCKMGVS RSASTVIAYA MKEYGWSLEK
     AYNFVKQKRN ITRPNAGFMR QLAEYEGILD ASKQRHNKLW HPDADCEMAE GQQGLTQFCG
     GEDGGDPTAD PGMSPCCEEG SSNKGAACSS PCRTVALNID PAYNNYYFRR LSDSALDSEP
     STPVRGPPLL GMEKVFIEIE DVERDALLDD EAFHGREGLP LPHFGPTAEG AAAQTCSRGP
     EPLEELRLRL EFSTVEEENE EDVQKEEAEM EVLMQPDDRG GGEGDGGETQ DVEVEGDAEG
     IGMDLASLND NSNNNNHLSL LQNHKDTSSS FLLQRDASLV SGSHQKERSS SPSSELRLTA
     RPPSEVQSAS SRHSQTSTEG VSSSTGLLSP CGPQCDCANC ATCATALSSS EAQRSAEAQD
     GSHLLQDGPS ESASDVLPEL MRADFEGETP AVACYLGQQQ ESLLQLRRSG LVRRRAERLE
     RLSGMSLQEC QKSKMCPSHS EEKEEFSSFT GDFAKTSTPC QVRLEPLVVP LTNEALLGVV
     GSGLLTPTSS PHGSTLTRSS SSDSLRSVRG KPGLVRQRAQ EIETRLRLAG LTVPSRLKRS
     NSLAKLGSLN LSSDDLRSAC SSDAGTLLLL SLSPEPDQGL EWDSPTASSL SRPSKNLLTP
     ERALPGEPRS
//
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