ID   A0A3B3TS78_9TELE        Unreviewed;       536 AA.
AC   A0A3B3TS78;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   Name=KPNA6 {ECO:0000313|Ensembl:ENSPLAP00000003226.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000003226.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000003226.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR   AlphaFoldDB; A0A3B3TS78; -.
DR   Ensembl; ENSPLAT00000011726.1; ENSPLAP00000003226.1; ENSPLAG00000000793.1.
DR   GeneTree; ENSGT01050000244950; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF8; IMPORTIN SUBUNIT ALPHA-7; 1.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   DOMAIN          1..58
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          122..165
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          165..193
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          334..365
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ   SEQUENCE   536 AA;  60234 MW;  AB56693AA66F8928 CRC64;
     MQYYPAKDNY RMNRYKNKAL NPEEMRRRRE EEGIQLRKQK REQQLFKRRN VDVLNEEEVM
     FESPLVDSYL NSPATEGVIT RDMVDMLFSE DPELQLATTQ KFRKLLSKEP NPPIDEVINT
     AGVVERFVEF LQKSTNCTLQ FEAAWALTNI ASGTSQQTKT VIEAGAVPIF IELLNSDFED
     VQEQAVWALG NIAGDSAVCR DYVLNCNILT PLLLLLTKST RLTMTRNAVW ALSNLCRGKN
     PPPAFEKVSP CLPVLSRLLF SSDPDLLADA CWALSYLSDG PNDKIQAVID SGVCRRLVEL
     LMHTDYKVAS PALRAVGNIV TGDDIQTQVV LNCSALPCLL HLLSSPKESI RKEACWTISN
     ITAGNRAQIQ TVIDANIFPV LIEILQKAEF RTRKEAAWAI TNATSGGTPE QIRYLVNLGC
     IKPLCDLLTV MDSKIVQVAL NGLENILRLG EQEAKQENNG TGVNPYCSLI EEAYGLDKIE
     FLQSHDNQEI YQKAFDLIER YFGVEDEDSS LAPQVDQANQ QFLFPQQEAP MEGFQL
//