ID A0A3B3TY70_9TELE Unreviewed; 616 AA.
AC A0A3B3TY70;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000005291.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000005291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR RefSeq; XP_014887101.1; XM_015031615.1.
DR AlphaFoldDB; A0A3B3TY70; -.
DR STRING; 48699.ENSPLAP00000005291; -.
DR Ensembl; ENSPLAT00000008194.1; ENSPLAP00000005291.1; ENSPLAG00000007171.1.
DR GeneID; 106946916; -.
DR KEGG; plai:106946916; -.
DR CTD; 43; -.
DR GeneTree; ENSGT00940000157637; -.
DR OrthoDB; 4386at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0003990; F:acetylcholinesterase activity; IEA:Ensembl.
DR GO; GO:0006581; P:acetylcholine catabolic process; IEA:Ensembl.
DR GO; GO:0071405; P:cellular response to methanol; IEA:Ensembl.
DR GO; GO:0030239; P:myofibril assembly; IEA:Ensembl.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR GO; GO:0050803; P:regulation of synapse structure or activity; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR CDD; cd00312; Esterase_lipase; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR014788; AChE_tetra.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR000997; Cholinesterase.
DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR PANTHER; PTHR43918:SF11; ACETYLCHOLINESTERASE; 1.
DR Pfam; PF08674; AChE_tetra; 1.
DR Pfam; PF00135; COesterase; 1.
DR PRINTS; PR00878; CHOLNESTRASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Signal {ECO:0000256|RuleBase:RU361235};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT CHAIN 24..616
FT /note="Carboxylic ester hydrolase"
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT /id="PRO_5017102673"
FT DOMAIN 29..565
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT DOMAIN 580..613
FT /note="Acetylcholinesterase tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF08674"
FT ACT_SITE 224
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 351
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 480
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
SQ SEQUENCE 616 AA; 69681 MW; 0DD06165D2E37513 CRC64;
MQLSTYLVFL SIFLIALIPT CFSQNDGDLV NTHSGLVQGA RFPVPDGSYV TAFLGIPFAE
PPLGKRRFRP PEPKRRWTGI LEANAYPNAC YQYVDTSYPG FQGTEMWNPN REMSEDCLYL
NIWVPASPRP HNLSVMVWIY GGGFYSGSSS LDVYDGRYLA HTETVIVVSM NYRIGAFGFL
ALHGSSEAPG NVGLLDQRLA LKWVQENIHS FGGNPKQVTI FGESAGGASV GFHLLSPDSR
PFFTRAILQS GVPNCPWASV SPAEARRRAT LLAKLVNCNG GNDTELVDCL RNKTPQELID
QEWLVLPWSA LFRFSFVPVV DGDFLPDTPE AMINSGNFKD TQILLGVNQD EGSYFLLYGA
PGFSKDNESL ISKEDFLEGV RLSVPHANDI GLEAVVLQYT DWMDENNGVK NRDAMDDIVG
DHNVICPLAH FARSYAQHHT LKANLGMMNS GGNSQGGVYL YLFDHRASNL AWPEWMGVIH
GYEIEFVFGL PLEKRLNYTT EEKNLSRRIM KYWANFARTG NPNDGLLDTR KRWPLFTANE
QKHVTLNTDP LKIHKGLRNQ MCAFWNRFLP RLLNITGNID EAERQWKVEF HRWSSYMMHW
KSQFDHYSKQ ERCTDL
//
