ID A0A3B3TYS8_9TELE Unreviewed; 1936 AA.
AC A0A3B3TYS8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ADP ribosylation factor guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSPLAP00000005496.1};
GN Name=ARFGEF1 {ECO:0000313|Ensembl:ENSPLAP00000005496.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000005496.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000005496.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
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DR Ensembl; ENSPLAT00000007847.1; ENSPLAP00000005496.1; ENSPLAG00000007534.1.
DR GeneTree; ENSGT00940000157108; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF137; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 752..941
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 220..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1908..1936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1911..1925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1936 AA; 216814 MW; 70BE8749DC1BE50D CRC64;
MYEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKAESEK LSPPSGDGKS
GSSTLPPIKS KTNFIEADKY FLPFELACQS KCPRIVITSL DCLQKLIAYG HLTGSAPDST
APGKKLIDRI IETICACFQG PQTDEGVQLQ IIKALLTAVT SQHIEIHEGT VLQAVRTCYN
IYLASKNLIN QTTAKATLTQ MLNVIFARME NQALQEVKQL ERERHRQQSP VAQHTEPESP
QLQTHVHPPG KAPAQEANGP VSPATPSIAT PSTPSTPSTP APESSSSRSA SGEREEPGEP
GERGERPAPD ENPDPENGSE FCVAENEQTE ADQATAAVQN AASKQHEGAG EEEDEEAPNY
EEKAQEIVQS ILQEVVNTVA GGHCLDPANL CSDTKESAAE PEESPPAEAA TEGTQSSMED
EGTVGSDSEH VHANGIPGTP ISASFTPSLP DDRLSVSSTD TQESGAAAGQ PPGAKFSHIL
QKDAFLVFRS LCKLSMKPLS DGPPDPKSHE LRSKVLSLQL LLSILQNAGP IFKTNEMFIN
AIKQYLCVAL SKNGVSSVPE VFELSLSIFL TLLSHFKTHL KMQIEVFFKE IFLYILETST
SSYDHKWMVI QTLTRICADA QSVVDIYVNY DCDLNAANIF ERLVNDLSKI AQGRAGHELG
TTPQQELTLR KKGLECLVSI LKCMVEWSKD QYVNPNSQTS LGQEKPSEQD SSETKATESI
NRYGSINSLD STASSGIGSY STQMSGTDNP EQFEVLKQQK EIIEQGIDLF NKKPKRGIQY
LQEQGMLGTT PEDLAQFLHQ EERLDSTQVG EFLGDNDRFN KEVMYAYVDQ MDFQGKDFVS
ALRMFLEGFR LPGEAQKIDR LMEKFAARYL ECNQGQTLFA SADTAYVLAY SIIMLTTDLH
SPQVKNKMTK EQYIKMNRGI NDSKDLPEEY LSAIYDEIAG KKIAMKETKE LTMKSSKQSV
ASEKQRRLLY NVEMEQMAKT AKALMEAVSH VQAPFTSATH LEHVRPMFKL AWTPFLAAFS
VGLQDCDDTE VASLCLEGIR CAIRIACIFS IQLERDAYVQ ALARFTLLTA SSGIAEMKQK
NIDTIKTLIT VAHTDGNYLG NSWHEIMKCI SQLELAQLIG TGVKARYISG TVRGKEGFIT
STKEQNNDEY LGLVGGTVDR KQIASIQESI GETSSQSVVV AVDRIFTGST RLDGNAIVDF
VRWLCAVSMD ELASPTHPRM FSLQKIVEIS YYNMGRIRLQ WSRIWEVIGD HFNKVGCNPN
EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKKNRSPTIR DMVVRCIAQM
VNSQAANIRS GWKNIFSVFH LAASDQDESI VELAFQTTGH IVTNVFEKHF AATIDSFQDA
VKCLSEFACN ASFPDTSMEA IRLIRHCAKY VSERPQAFKD YTSDDMNVAP EDRVWVRGWF
PILFELSCII NRCKLDVRTR GLTVMFEVMK TYGHTFEKHW WQDLFRIVFR IFDNMKLPEQ
QTEKAEWMTT TCNHALYAIC DVFTQYFESL NGLLLDDILA QLYWCVQQDN EQLARSGTNC
LENVVILNGE KFSAETWDKT CNCMLDIFKT TIPHALLTWR PAGAEGEHFA THSLTDKQLD
SISQKSVDIQ SRSDDQHSIS SGDRATAMES RRQSQHSSAS GVFEDGSRSR TSTKIQEQRL
FSALLIKCVV QLELIQTIDN IVFFPATSKK EDAENFAAAQ RDAGCAADVQ VETQDQGMFR
YLTSEQLFKL LDCLLESHRF AKAFNSNNEQ RTLLWKAGFK GKSKPNLLKQ ETSSLACGLR
ILFRMYTDES RQDAWEEVQR RLLNVCSEAV AYFLALTSES HREAWTNLLL LFLTKVLKIS
DERFKAHASR YYPLLCEIMQ FDLIPELRAV LRKFYLRIGL VFNIAQLPEP EPDPEPRRAE
PETDMEVGEE AGEEAQ
//
