ID A0A3B3TZ57_9TELE Unreviewed; 1356 AA.
AC A0A3B3TZ57;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000005913.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000005913.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR Ensembl; ENSPLAT00000007133.1; ENSPLAP00000005913.1; ENSPLAG00000008044.1.
DR GeneTree; ENSGT00940000157151; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..117
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 119..210
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 217..312
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 315..416
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 422..523
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 836..1067
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 987..1058
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1099..1348
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1278..1353
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1356 AA; 152485 MW; A4AF2132378ACA70 CRC64;
MLVNSSQHAA GHRAQLLLQT LSENDTHCVQ FSYFLYSRDG HSPGALRVYV RVNGGPLGSP
VWNTSGSHGK QWHQVELAVS TFWPSEYQVL IEATVSRERR GYIALDDILV LNYPCYKAPH
FSRLGDEEVN AGQNATFQCV AAGRASEAEK FLLERHNGDI LTAASVKHLS HRRFVVSFQL
DSVQRSDQDL YRCVTQSSRG SGVSNFAELV VKVPPSPIAP PQLLRAGSTY LIIQLNTNSI
LGDGPIIRKE IEYRASQSPW SEVHGVNMVT YKLWHLDPDT EYHISVLLTR PGEGGTGPPG
PPLVSRTKCA EPMRPLRGLV ATDIQSRQLS LQWENLAFNL TRCHTYSVSL CYRYTMAGGG
GGHNTTIREC LAVEHNASRF TLRDLPPYHG VHVRLSLANP EGKKESREVS FQTEEDIPGG
IAPESLTFTP LDDMIFLKWE EPVEPNGLIT QYEISYQSTE SSDPGINVPG PRRTVSKLKN
ETYHMFSNLH PGTTYLISVR ARTAKGFGQT ALTEITTNIS APTFDYGDMP SPLGETDHTI
TVVLRPAQGR GAPVSTYQVV VEEETVKKVK RELGLQECFP LPMSHGEAQA RGTPHYYTAE
LPPSSLPEAF TVGDNHTYNG YWNTPLDPRK SYLVYFQAMS NFKGESRINC IRIARKVACK
DHQRALEVSQ HSEEMGLILG VCVGGLVILI LLLGAVIIII KKGRDHYSYY PKPVNKTPIT
YRQEKSHMGS LERSFTDQST LQEDERMALS FMDAHTCGTR SDARSSVNEA SSLLGGSPRH
QCGRKGSPYH TGQLHPAVRV ADLLQHINQM KTAEGYGFKQ EYESFFDGWD CTKKKDKTKG
RHDTLLGYDR HRVKLHPLLG DPNSDYINAN YIDGYHRSNH FIATQGPKQE TLYDFWRMVW
QENCFSIVMI TKLVEVGRVK CCKYWPDDSE MYGDIKISLL KTETLAEYTV RTFALERRGY
STKHEVRQFH FTSWPEHGVP YHATGLLAFI RRVKASTPPD AGPVVVHCSA GAGRTGCYIV
LDVMLDMAEC EGVVDIYNCV KTLCSRRINM IQTEEQYIFI HDAILEACLC GETAILVNEF
AVTYKEMLRV DSQSNSSPLR EEFQTLNSVT PHLDVEECSI ALLPRNREKN RSMDVLPPDR
ALAFLVTTEG ESNNYINAAL ADSFHRQAAF IVTPHPLPGT TADFWRLVFD YGCTAVVMLN
QLNQSNSAWP CVQYWPEPGL QQYGPMEVEF LSMSADEDVI TRLFRVKNVT RLQEGQLVVC
QFQFLRWSAY RDVPDSKKAF LNLLAQVHKW QRECGEGRTV VHCLNGGGRS GTFCACNILL
EMIQYQNMVD VFYSVKTLRN CKPNMVESLV KIKNKK
//
