ID A0A3B3TZD4_9TELE Unreviewed; 1936 AA.
AC A0A3B3TZD4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Myoferlin-like {ECO:0000313|Ensembl:ENSPLAP00000006560.1};
GN Name=MYOF {ECO:0000313|Ensembl:ENSPLAP00000006560.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000006560.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000006560.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 48699.ENSPLAP00000006560; -.
DR Ensembl; ENSPLAT00000006045.1; ENSPLAP00000006560.1; ENSPLAG00000008810.1.
DR GeneTree; ENSGT00940000154741; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF55; MYOFERLIN; 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1901..1923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 264..400
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1018..1144
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1181..1305
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1416..1534
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1650..1800
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1852..1874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1852..1869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1936 AA; 221141 MW; 0D6C335D2B2F8AA5 CRC64;
MLRVIVESAS GIPKKKIGNP DPIATVLFRG EKKKTKAINN DLNPVWNEVL EFDLKGSLLD
ASSYLDVIVK DYETIGKHKF IRSAKISLRD LASGQVKSLP CKNVPLINEK QQNVGVNKFL
SFLLYFKIQI RVRVIEGRQL PGNNVKPVVK VNVCGQTHRT RIRRGNNPFF DEMFFYNVNM
LPSELFDESI SLRVSIMFLF MKQPFLLDVG YIYNEPGHSI MRKWLLLSDL EESSTGARGY
LKVSIIIVGT GDDPPSERRE LNEEQDDIES NLLVPAGVTM RWATLSLKVF RAEDMPQMDD
AFVQTVKQVF GGDGDKKNLV DPYLEVSFAG KKFCTKIIEK NANPEWNQVI RLQVKFPSMC
ERVKLTMYDW DRLSKDDAIG TTFLNLSKMS CSGGEIEGNV GGFLPAFGPC YVNLYGSPRE
FTGLPDPYEE LNFGNGEGVA YRGRVLVELS TQVDGKVDKN VDDICSDDIL VAQKYQRRRK
YSLCAVFHSA CMLQEPGEPI QFEVSMGNYG NKLDSTCKPL ASTTQYSFAV FDGNHYYYLP
WADTKPVVIL TSYWEDISHR LDAVNVLLFI VDQLVRQVLD VRKEIQAKVS EAQLTEVLLS
LLNHLIENIN NLQLPTLEGQ HNITALDLQI KSLREAALAS IRAAACQMTE ETLDVKSVVG
DIEEWLERIK VLADEAQNSM PDVIIWMLRG EKRVAYARVP VHQILFSNYS EQACGKHCGK
TQTVFMQYPM DKNKGVKIPV QLRINMWLGL SAYEKKFNSF SEGNFSVYAE MYENQAQVFG
KWGTTGLVGR HKFSDVTGKV KLKQERFLPP RGWEWEGDWF VDPERCLLTE ADAGHTEFID
EVFQNETRFP GGEWKPAAEP YTDVNGEKSQ SPEDFECPPG WNWEDVWSFD SDRAVDEKGW
DYGVVIPPDD KPKSWVAAEK MYHNHRRRRL KRKRRKISDK VTATEKRESG EGWEYSSLIG
WKFHRKERSS DTFRRRRWRR KMVPSDCIGA SAIFRLEGAL GVDVDEKASK TDAAKPFGAN
TPTVSCHFTR FYLYHLRVYV YQGRNLCAMD KDSFSDPYAH VSFLHVSKTT EVIRTTLNPT
WDQTLIFEDI EIFGDPQAIE RNPPDVVFEL YDSDQVGKDE PMGRCLCPPV VKLPSKSPSL
SDSLKLQWLP VTKKGCGAGE VLVAAELILK EKDLPLVPPR RGENLYMVPQ GIRPVVQLTA
IEVLTWGLRN MKSFQLAAVS SPSLTVECGG EMVQTAVIKN FKKHPNFPGS VLLLKVLLPK
EEMYAPPIVL KVVDHRPFGR KPVVGQCTID CLEQFRCDPY RPNSDVCMSA RDVVIDIEEG
NVLKTQEDEA VDWWSKFYAS VGQHEKCGPY LKLGYDKLQV YDTELEEVPE FQGLTDFCST
FKLYRGKTED EQEDPSVVGE FKGSFRIYPL PGQGERAPPL QFRERPELGP QECLVRIYVV
RGIDLQPKDT NGLCDPYIKI TLGRKTIDDR DNYKPNTLNP EFGRMFELSC FLPLETDLKI
AVFDFDLLSR DEKVGETVID LENRFLSCFR SYCGLPETYC VSGINQWRDQ LRPSQILQNL
AKEKALLPPH IDENGSSLSF AGKQYKLQDY EGNSVIHQHL GPARERLALH VLRDQGLVPE
HVETRTLHSS HQPNLPQGKI QMWVDIFPKS QGLPGPPCVI TPRKAKKYFL RVIVWNTTEV
TLDETSVTGE NMSDIYVKGW MPGMEEDKQK TDVHYRSLDG DGNFNWRFIF GFDYLPAEQL
CVASRKEHFW NLDKTEHRFP PKIVIQIWDN DKFSLDDYLG SVELDLLNLM PPAKTPEKCS
LKMLSGKRRN VSPSLFTQKS VRGWWPCAVE KDGKQELGGK VEMTLEIVEE KEMEERPAGK
GRDEPNMNPK LDPPNRPDTS FFWFTNPCKT MKFIIWRRFK WVFLGLILLL LVILFLGILF
YSLPNYISMK IVKPFS
//