ID A0A3B3U279_9TELE Unreviewed; 553 AA.
AC A0A3B3U279;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transcription factor 7-like 1-A {ECO:0000313|Ensembl:ENSPLAP00000006737.1};
GN Name=TCF7L1 {ECO:0000313|Ensembl:ENSPLAP00000006737.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000006737.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000006737.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR AlphaFoldDB; A0A3B3U279; -.
DR Ensembl; ENSPLAT00000005754.1; ENSPLAP00000006737.1; ENSPLAG00000008972.1.
DR GeneTree; ENSGT00940000157038; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF25; TRANSCRIPTION FACTOR 7-LIKE 1; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 321..389
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 321..389
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 60523 MW; 0D402CC57B198EA9 CRC64;
MPQLNGGGGD DLGANDEMIS FKDEGEQEEK ISENVSAERD LDDVKSSLVN ESENNSSSSD
SEKTSRFCLS KPLSFPFSSA ALRRQQDGGF FKSPHYPGYQ FLMFPDLTNP YLSNGSLSPS
ARTYLQMKWP LLDVPGSAGI KDSRSPTPGH LSNKVPVVQH AHHVHPLTPL ITYSNEHFSP
GTPPSHLSPE ILDPKTGIPR TPHPSELSPY YPLSPGAVGS IAHPLSWFMQ QQGQPMYSIP
PGGFRHPYPT LAMNASMSSL VSSRFSPHMV TPPPHSLHQT GIPHPAIVSP AIKQEPSGDN
ISPSMKSPVP SKKEEDKKPH IKKPLNAFML YMKEMRAKVV AECTLKESAA INQILGRRWH
SLSREEQAKY YELARKERQL HSQLYPGWSA RDNYGKRKKR KRENKPDSKP EGKSKKQCVQ
YLPSEKMCDS PASSHGSMLD SPATPSAALA SPAAPAPTHS EQAQPLSLTT KPEGRMHHHF
SVPGKASGSP SIAIPVGTLG SQSSTPILTR PIPFTSLHPS MLSPPSPFHQ AALHSHHSLF
QSQPLSLVTK PTE
//
