ID A0A3B3U2W2_9TELE Unreviewed; 1040 AA.
AC A0A3B3U2W2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN Name=FARP1 {ECO:0000313|Ensembl:ENSPLAP00000006947.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000006947.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000006947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR AlphaFoldDB; A0A3B3U2W2; -.
DR STRING; 48699.ENSPLAP00000006947; -.
DR Ensembl; ENSPLAT00000005383.1; ENSPLAP00000006947.1; ENSPLAG00000009174.1.
DR GeneTree; ENSGT00940000155318; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17189; FERM_F1_FARP1; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 43..323
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 535..726
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 755..852
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 927..1024
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1040 AA; 118721 MW; 43AB11A77FF058C1 CRC64;
MAEPDPENLS SGAGQRLGAP ETLGISTLDP GHKPPAMPPG RHVTVTVRML DDTEEVFDVS
QKASGKVLFD LVCSHMNLIE GDYFGLEFQN HKSMMVWLDH IKPIIKQLRR PKNTTLRFSV
KFFPPDHAQL LEELTRYLFA LQIKQDLSSG RMTCNDTSAA LMVSHIIQSE IGDFDESHCR
SHLLNNNYIP DQMPLIDKIM EFHSKHIGQS PAESDFQLLE VARKLDFYGI RLHPAKDREG
SKLNLAVAHT GVLVFQTHTR INAFNWSKIR KLSFKRKRFL IKLRPDLNSS YQDTLEFLMA
SRDCCKVFWK ICVEYHAFFR LFEEPKPKPK PMLFTRGSSF RFSGRTQKQV IDYVRESEFK
KIPFERKHSR VRYSSRVQHN SRLSPLPSPR HHEVPSESGV PEDLSSSSPP RRHWKESVLV
SAEDPAASRT SKMSPNHQRN GHEDRKESVS KPEESRGSTQ QMSPEHPSQG VAPHSPPPSG
HPHGMVNGQK SLELCSHSLD GRQPSPLTSP LLNDACSIRT DDEDEVRRKR FPTDRAYFIA
KELLTTERTY LKDLEVVTVS FQSVVGQDEE TPDSLKNTIL STFEPLHKFH TGFLREVEQR
LAIWEGRSNA HIKGDCQRIG DVMLKNLQAL KPLTTNMHKH SDILLELEKA CKASRRVENL
CRDFELQKVC YIPLNVFVLR PLHRLIHYKQ ILERLCKHYP ATHEDFRDCR AALADVSEVV
DQLQGSLIKM ENLQTLLELQ KDLLGVDNLV VSGREFIRLG CLSKLSGKGL QQRMFFLFND
VILYTSRGMT PTNQFKVHGQ LPLRGMTIRE SEEEWGVPHA FTLVGQGQSV VVAASSLTEM
EKWMQDIKMA IETAKTSNGP TSDVLTCTLT DNKCPEDSSA EAESEDDTSA LNTSLEKPAA
HRGNTMVHVC WHRSTSVSMV DFSVAVENQL SGNLLRKFKN SNGWQKLWVV FTNFSLFFYK
SHQDDYPLAS LPLLGYSVTV PAENENIHKD YVFKLHFKSH VYYFRSESEY TFERWMEVIR
SATVSSSQAR LLNSKDPHPH
//
