ID A0A3B3U352_9TELE Unreviewed; 513 AA.
AC A0A3B3U352;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Uncharacterized LOC106949175 {ECO:0000313|Ensembl:ENSPLAP00000007880.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000007880.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000007880.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC Evidence={ECO:0000256|ARBA:ARBA00001432};
CC -!- SIMILARITY: Belongs to the SAMHD1 family.
CC {ECO:0000256|ARBA:ARBA00005776}.
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DR AlphaFoldDB; A0A3B3U352; -.
DR STRING; 48699.ENSPLAP00000007880; -.
DR Ensembl; ENSPLAT00000003826.1; ENSPLAP00000007880.1; ENSPLAG00000010358.1.
DR GeneTree; ENSGT00390000013867; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..268
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 513 AA; 60811 MW; B39C225EB05C4A92 CRC64;
MNLFYSWHEF VLFQMIKNKK EASADASISR SVTGVFRYFS FLVFTCWFPL LIWMFETRCC
PYMKLHVFVW QVFKDSVHGS LELHPVLVKI IDTPQFQRLR NIKQLGGTYY VYPGASHNRF
EHSIGVAHLA GELLQTLKKK QQKLRIDERD VLCVQIAGLC HDLGHGPFSH MFDQMFIPKA
RPGYDWSHEK ASQDMFDHLV EENELNKFME DHGLVPKEDL PFIKELIDPP NVKTIEWPHH
GRPREKAFLY EVVSNKRNKI DVDKWDYFAR DFHHLGMKNN FDCHRLIKFA RVCEVDEEMQ
ICYRDKEGFN LYNMFYTRFC LHKRACQHKV ANSIEWMITD AFLKADKHIK IEGKDGKMFT
LSTAIDDMVA YTKLTVKKIL NHLSADRDIK KGKEILDRVL KRDLYRCWGE FHSNKSSKEI
KVSEIKLDYG KQDKDPIEDV RFYQKDDPDK AEELKRDDVS NLLPAKFEET IIRFYCKRTN
DPEAGKQQFK KFKSTHDKFP ALMKLPYNKL LKY
//
