ID A0A3B3U6F0_9TELE Unreviewed; 512 AA.
AC A0A3B3U6F0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Syntrophin beta 2 {ECO:0000313|Ensembl:ENSPLAP00000008910.1};
GN Name=SNTB2 {ECO:0000313|Ensembl:ENSPLAP00000008910.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000008910.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000008910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the syntrophin family.
CC {ECO:0000256|ARBA:ARBA00010798}.
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DR AlphaFoldDB; A0A3B3U6F0; -.
DR Ensembl; ENSPLAT00000002093.1; ENSPLAP00000008910.1; ENSPLAG00000011593.1.
DR GeneTree; ENSGT00950000182863; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01258; PHsplit_syntrophin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR041428; PHsplit_syntrophin.
DR InterPro; IPR015482; Syntrophin.
DR PANTHER; PTHR10554:SF8; BETA-2-SYNTROPHIN; 1.
DR PANTHER; PTHR10554; SYNTROPHIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF18012; PH_17; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}.
FT DOMAIN 82..165
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 295..407
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 43..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 55881 MW; 0A8D306C2156D7B5 CRC64;
MAVWTRADKN GQLDLLLRDR WIRVGAELTR ETLTLTAEAE VNGANSDFGS PGSGYGSPGS
SFGSRQGDPP VNLDGSSEAV RKVRVVKQES GGLGISIKGG RENRMPILIS KIFPGLAADQ
SRALRVGDAI LSVNGNDLRE ATHDMAVQAL KKAGKEVTLE VKYIREVSPL FKKPSLVADL
QWDGVRPQSP SYSGSDDSGS PKHSSSSSSS KDRKVISLKM CFISRNLTMP DLENRLLELH
SPDGQHTVVL RCKDGATANS WFTAIHTNIA ALLPQTLAHI NAYLGASSAA STHPHLKHIG
WLAEQIQLEG GRQQFRPVVM ALTEKDILLF ESVPWSRESW SMPLLTHPLL ATRLVHSGSA
RGSPSHGSDL VFATRTGTGR GIESHVFRVE THWDLSTWTR ALVQGVHAAA EIIKEVSIGC
TLNRQDVRLT LHYEKGFTIT REPADQTGGA VLFRYPYEKL KMSADDGIRN LYLDFAGPEG
EMVFDLHSGP KPVVFVLHSF LSAKLTRMGL LT
//
