ID   A0A3B3U6V7_9TELE        Unreviewed;       814 AA.
AC   A0A3B3U6V7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Breast cancer anti-estrogen resistance protein 3-like {ECO:0000313|Ensembl:ENSPLAP00000008339.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000008339.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000008339.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3U6V7; -.
DR   STRING; 48699.ENSPLAP00000008339; -.
DR   Ensembl; ENSPLAT00000003052.1; ENSPLAP00000008339.1; ENSPLAG00000010910.1.
DR   GeneTree; ENSGT00940000154130; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd09487; SAM_superfamily; 1.
DR   CDD; cd10337; SH2_BCAR3; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR   PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR   PANTHER; PTHR14247:SF11; SH2 DOMAIN-CONTAINING PROTEIN 3A; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          1..64
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          165..264
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          545..808
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          279..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..351
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  92352 MW;  1C726364764E65F4 CRC64;
     MNNRSIAWWL RQIDLPQYTR SLESEYYGLE GLLYVTDGEL RDAGIEDATH RETILTQLSR
     DRQRLDPPSG QTQSTHTVRY VHRAGGKTCF KRFSYLKSIF DLFRHRVLPR LHRIDKKHRL
     SASCSQLRPL DEDNMFGGRK EMDILKKELE EELKLSTEDL RSHAWYHGPL RREAAEPLFE
     SDGDFLVRDS SSTPGDYVLS CFWKNGPHHF KIIKVVLRPK KGYSRELFQF EEDRFDNVPA
     LIRFYVGGNR PISKTSGAII SHPINRTLPL RVIGEGHMEL KNSSSGTIGR GRENQAGSSK
     RRSLSSSHQD TLQLINPLLR SGSQPANLEN VGRRPSLQSA QSDSNLRTVP PDDTDSDPIS
     PVFRTGSEPL LSPRSHHTLH SSLPPGGGAT FRGSDGQLHP RAPPKPLRVS TVFSNASPLP
     STDPDEDPSS YYSELIIRVP QSQRKGHVDR LRAEEKWQSR ARLTETSFGF LEAQNNGPSS
     QLLFQKEIQR KAAEEERDWH FERPHIETSS CFQLDQFTSL LLPDHNRPLE SNVLLAVKEL
     FSRSDAKSLA LHMLSVDCQV ARIVGVTDEQ KRIMGVNSGL ELVTLPHGHQ LRQDLLERHH
     LITLGVAVDI LGCTGTVNQR AMVLHKVILL AQALKEHVYD LFSFSAVMKA LDMTQVIVRL
     EMTWRALRRN HTDCAVLYEK KLRPFMNSLN EGNDSVVRGP IAVPHLVPLL MLMEGEDPVE
     NNDRGCQVLY DVLQSARSAA LHSQVYQKNA QTLLTADWTP VPELLETFRT EFALRLFWGQ
     QGATADKKER YEKFDKILCV LSDKLEPVEL TLTV
//