ID A0A3B3U8I3_9TELE Unreviewed; 490 AA.
AC A0A3B3U8I3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Thiamine transporter 1-like {ECO:0000313|Ensembl:ENSPLAP00000009615.1};
GN Name=SLC19A3 {ECO:0000313|Ensembl:ENSPLAP00000009615.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000009615.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000009615.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR028739}; Multi-
CC pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
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DR AlphaFoldDB; A0A3B3U8I3; -.
DR Ensembl; ENSPLAT00000000910.1; ENSPLAP00000009615.1; ENSPLAG00000012746.1.
DR GeneTree; ENSGT00950000183022; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF35; THIAMINE TRANSPORTER 2; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 209..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 55183 MW; FB72244A13C43D63 CRC64;
MECYALTLSS DWRYPTTLLC VYGFFSTVKP LEPFLIPFLT GPDKNLTTEQ VNNQIFPVWT
YSYLSVLVPV FLLTDWLRYK TVVVFQCVML FITTALLRWT ESVPAMQAMQ FCYGVVTASD
VAYFSYIYSV VDLKRYRKAT SYSRSVQLLG YTVGSVLGQL LVSFDLMSYD NILVFTLVLT
AVALVASCLL PVPQRSMFFH RKLSGQRASE EGAKRHRGGS EGEERDSETS NTSLGDKGDT
KEEQRAEEDE DSEEIKGEAS CSQVVLQLWR DFRQCYSSRQ LLYWSVWWAM ATCGYNQTVN
YIQVLWEHVQ PSQNFSIYNG GVEAASNLLS AATAYGIGFT EVRWEQWGEL ALGGFSGLGA
AALFLMTFAG NIWVCYATYT IFKCLYMLLI TIAMYQIAAD LSMERYALVF GANSFGALLL
QTIITSVVVD SGALGLPIVP QFIIYASYFS VISVVFLLRG IFSVCKAQRI KKEQLSLDGK
QSEICEEHKF
//
