ID A0A3B3U8L2_9TELE Unreviewed; 419 AA.
AC A0A3B3U8L2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000008984.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000008984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
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DR RefSeq; XP_014903536.1; XM_015048050.1.
DR AlphaFoldDB; A0A3B3U8L2; -.
DR STRING; 48699.ENSPLAP00000008984; -.
DR Ensembl; ENSPLAT00000001964.1; ENSPLAP00000008984.1; ENSPLAG00000011730.1.
DR GeneID; 106956936; -.
DR KEGG; plai:106956936; -.
DR GeneTree; ENSGT00390000004237; -.
DR OrthoDB; 5486419at2759; -.
DR UniPathway; UPA00628; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
SQ SEQUENCE 419 AA; 46501 MW; C948A374D543FB94 CRC64;
MAARNQVPLK ENGLQDGGRH VAALVLARGG SKGIKLKNIK PLAGIPLLGW VLRAAIDSGM
FNSIWVSTDH DEIEKVAKTW GAKVHRRSPE VSKDTSSSVE TIQEFLRNNT EVDVVCNIQA
TSPCLHPSHL QKALKMIMED GYESVFSVVR RHEFHWKEVK KGSGELTEPI NLVPALRPRR
QDWDGELHEN GSFYISSRDL IFKENSLQGG KVAYFEMEPE HSVDIDVDID WPLAEQRVLR
YGYFGRGVSL IFCRVSGCLT DGRVFLSVSG EDMVCVHSRD TTGLRMLQND GVEVVLLTSR
DDPVTQSLSG KLKTMLSCEV VDVGDEPLKD VQEVMEQRKL SWKNVAYMGN DTSDASCLNL
AGLSGVPADA SKEAANAGSF ACRQAAGMGA LREFAEHILQ QTEKAKKQMK QDRIDRNNF
//
