ID   A0A3B3U8Z5_9TELE        Unreviewed;       569 AA.
AC   A0A3B3U8Z5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN   Name=TTYH3 {ECO:0000313|Ensembl:ENSPLAP00000009790.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000009790.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000009790.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR   AlphaFoldDB; A0A3B3U8Z5; -.
DR   STRING; 48699.ENSPLAP00000009790; -.
DR   Ensembl; ENSPLAT00000000609.1; ENSPLAP00000009790.1; ENSPLAG00000012621.1.
DR   GeneTree; ENSGT00950000183060; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424:SF4; PROTEIN TWEETY HOMOLOG 3; 1.
DR   PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        59..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        101..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        226..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        254..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   REGION          428..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..535
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..557
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   569 AA;  63744 MW;  77FDBCF3483C6BAD CRC64;
     MPTGTKETTS SSCLPSIAVV SYSPPWWVNL LHRLPHFDLK FQQTSSDFQP EDWTYQQSIL
     LLGGLALACL VLDLLFLLFY SIWLCCRRSK TSEQPNADCC GTAWCVIIAT LVCSAGIAVG
     FYGNGETCDG VNRLTYSLRH ANRTITGVQK LVYDSTSSLN QTVDKNLQQL EGQYAQHADY
     LSIIQKLQGQ LDELVRQMVE IPFWDNNLIS LEDLSTSIEL YDWYRWLGYI TLLLFDILIC
     LLVLFGLIRN SKGILLAVWL FGVVAIIISW VSLGLELAVS ASSSDFCFAP DTYVTTVVYQ
     YEVIDKEVLQ YYLSCSPEQT NPFQQRLSGS HKALVEMQDD VSELLRSATR EYKQTRGSLE
     EIQGILNTTE ISLHQLTALV DCRSLHMDYV QGMTGLCYDG LEGLIYLLLF SFVTALMFTS
     IVCSTPHTWR GKRSDEDSVD ESLSPGGRQT HDSLYRVHMP SLYSCGSSYG SETSIPATAH
     TVSNAPVTEY MAQNSNFQNS RCENTPLIGR ESPPPSYTSS MRAKYLANSR PNPNSRPDPN
     SRPDHNSRPD PNSRPDHNSR PDPNNSPAH
//