ID   A0A3B3UGW9_9TELE        Unreviewed;       540 AA.
AC   A0A3B3UGW9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000011899.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000011899.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
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DR   AlphaFoldDB; A0A3B3UGW9; -.
DR   Ensembl; ENSPLAT00000029365.1; ENSPLAP00000011899.1; ENSPLAG00000015425.1.
DR   GeneTree; ENSGT00390000010463; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   HAMAP; MF_00313; Glutaminase; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   NCBIfam; TIGR03814; Gln_ase; 1.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          11..94
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
FT   REPEAT          457..479
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   540 AA;  60709 MW;  5E667FBDF638398A CRC64;
     MTNQYKVISG VEDMLFYTIT EGRDQVPISY FNAALKKTGL QPSDPRLREC MEKLRRAVKD
     SVGEVMMDRD LFHRCVGGNV VLLIQAFRKK FIIPEFDVFA EKINEIYKTD QEQSDGKVAD
     YIPQLAKFSP ELWGVSLCTV DGQRHSVGDT KQPFCLQSCV KPLQYAIAVH ESGTEKVHNY
     VGMEPSGLKF NVLSLDEEDK PHNPMVNAGA ILISSLIKPF SNKAEKFDYV MEFVKKMAGQ
     EYVGFSNATF QSEKETGDRN FAIGYYMKEK KCFPPGADMI DALDFYFQLC SIEVSCESGS
     VLAATLANGG ICPITGERVL SAEAVRNTLS LMHSCGMYDF SGQMAFHVGL PAKSGVSGAI
     LLVIPNVMGV MCWSPPLDRV GNSVRGIHFC QELVSQFNFH NYDNLRHFVK KQDPRRQDGD
     DRNKSVFNLM FAAFSGDVSA LRRFALSSVD MDLKDYDSRT ALHIAAAEGH IDVVKFLIDT
     CKVDPFVQDR WGNLPVDDAL QFGHEEVVKM LREYQQDWKQ QEMQHGEAEP RKLDTIEGMV
//