ID   A0A3B3UIJ2_9TELE        Unreviewed;       710 AA.
AC   A0A3B3UIJ2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=SH2B adaptor protein 3 {ECO:0000313|Ensembl:ENSPLAP00000012489.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000012489.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000012489.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SH2B adapter family.
CC       {ECO:0000256|ARBA:ARBA00010220}.
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DR   RefSeq; XP_014883765.1; XM_015028279.1.
DR   AlphaFoldDB; A0A3B3UIJ2; -.
DR   STRING; 48699.ENSPLAP00000012489; -.
DR   Ensembl; ENSPLAT00000029593.1; ENSPLAP00000012489.1; ENSPLAG00000015802.1.
DR   GeneID; 106944941; -.
DR   KEGG; plai:106944941; -.
DR   CTD; 10019; -.
DR   GeneTree; ENSGT00950000183191; -.
DR   OrthoDB; 2995825at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01231; PH_SH2B_family; 1.
DR   Gene3D; 6.10.140.110; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR   PANTHER; PTHR10872:SF1; SH2B ADAPTER PROTEIN 3; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          482..580
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..645
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  77763 MW;  472496C99604D114 CRC64;
     MNGNTIHPAN TTSAGGGPSV AAPPRGWREF CELHAIATAR QLAGHYRSFA SERPQHELVP
     PETFSKHFTD LFQQHFCQEV DKDGASGSAS ATAPSPHALI NQLRHSTLSQ DYREAKRSSG
     GAASISTVPK VEPVVVSPEP ELPLRCAARN SFSGSRSVGG GSLLIQSHSN DEISAADRHQ
     PSERHSSDSL VPGSGGHGDI THFPVSQIQK TVQWIFQKRQ SRSSHSSQDL SPTNPNPATA
     NNSPSNNGDR VDEGSSSSSS SQSFSFQNFE ATAPATLHRP RVVSHLLEGF RWLRSRSMRL
     RRLDVSGCCK EGQLKYLLVD DTISDSQPHW QRCRLLVRRI RDTQSGGGRA GSERYQLELY
     DPPKASSPKL TTHCSDIQEV RRCTRLEMPD NLNTFVLKVN RGSLIFETDN DQQVSSWTTE
     LKECISNRSG SVDLECPLSS ADSSAPANQR RSSDSGRQSP VTFALPEQVI QKADDFLVSF
     PWFHGPISRV KAAHLVQSSG PEGHGVFLVR QSETRRGDFV LTFNYQGKAK HLRLSLNEWG
     QCRVQHLRFP SVMDMLSHFR LYPIPLECGA AGAVTLSSFV LAGSTPPSQG QLSGALLVPF
     SLHRWSSEPS LARCSLARSS SQPPAFSPTP TSTTSTSSPG SFSQFGRVVP TAEPAPSAPA
     HLRRSESVGR RPLLRSPNPH APIIPQRDSD YELEPDRGRK RAIDNQYMLL
//