ID A0A3B3UIT6_9TELE Unreviewed; 555 AA.
AC A0A3B3UIT6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
DE EC=5.2.1.8 {ECO:0000256|PROSITE-ProRule:PRU00277};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000012646.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000012646.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000256|PROSITE-
CC ProRule:PRU00277};
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DR AlphaFoldDB; A0A3B3UIT6; -.
DR Ensembl; ENSPLAT00000020415.1; ENSPLAP00000012646.1; ENSPLAG00000016145.1.
DR GeneTree; ENSGT00940000156331; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.50.40; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR PANTHER; PTHR46046:SF3; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP10; 1.
DR PANTHER; PTHR46046; PEPTIDYLPROLYL ISOMERASE; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF00254; FKBP_C; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF54534; FKBP-like; 4.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50059; FKBP_PPIASE; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Rotamase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..555
FT /note="peptidylprolyl isomerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017268655"
FT DOMAIN 46..134
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT DOMAIN 158..246
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT DOMAIN 270..358
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT DOMAIN 400..456
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT DOMAIN 467..502
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 512..547
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 555 AA; 61750 MW; 0202B7D7BE0E7672 CRC64;
MLPLCVVFSV LVAWFSVESN PSPVLGDVVV DRYEIPKDCV REAKTGDYVR YHYNATFTDG
KTLDSSYEKG AAKVGLIGEG RLIAGVDKGL QGMCVNERRK ITIPPHLAYG SSGAGDAVPP
DATLVFDIHL LDLWNKADLV VTRTVSTPKD CKRSVMRTDF VRYHFNGTLL DGTTFDSSYN
RKQTYNSLVG EGWLVKGMDE GLLGMCVGEI RHIVIPPFKA YGEKGSGTMI PPQATLVFDV
LLEDIHNPKD NITIENQEAP EPCTRRSVAG DYIRYHYNGT FLNGVTFDTS YQRNSTYNTY
IGMGYVIPGM DQGLLGVCLG ERRRVIIPPH LAYGEQGAGD VIPPSAVLVF DVHVIDFHNP
SDKVEIEVTY KPEVCNDTTT LNDLVRYHYN FEHGFHLDVL GQDKVIDGLD EGLRGMCVGE
KRRITVPPHL GHGERGAAGV PSSAVLVFSI ELVSFERGVP PGYLFVWLEE TPADLFETMD
MNKNGEVPLD EFTEFIKLQV AEGKGRIKPG MTMEQIVADM FQNQDRNKDG MITASELKLK
VEEDKEREQA RHEEL
//
