ID A0A3B3UJ37_9TELE Unreviewed; 391 AA.
AC A0A3B3UJ37;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Pseudouridylate synthase RPUSD4, mitochondrial {ECO:0000256|ARBA:ARBA00039953};
DE AltName: Full=RNA pseudouridylate synthase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00041563};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000013370.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000013370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in mRNA = a pseudouridine in mRNA;
CC Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001166};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA = a pseudouridine in tRNA;
CC Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00036943};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA;
CC Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001896};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014908858.1; XM_015053372.1.
DR AlphaFoldDB; A0A3B3UJ37; -.
DR SMR; A0A3B3UJ37; -.
DR STRING; 48699.ENSPLAP00000013370; -.
DR Ensembl; ENSPLAT00000021338.1; ENSPLAP00000013370.1; ENSPLAG00000016848.1.
DR GeneID; 106960329; -.
DR KEGG; plai:106960329; -.
DR GeneTree; ENSGT00940000158436; -.
DR OrthoDB; 2901925at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF93; PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 4: Predicted;
FT DOMAIN 127..302
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT REGION 34..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 43743 MW; C64302563EBB5071 CRC64;
MNCGKAVAVL GDQMFFLLVK SRTICRRLPG TAPVLSRSQH TAAERDSPGG SDTAEKPRLR
AIDLARKIRQ EKAKTRSETR TQDRDPPVSG SQQRVTELKR FTAQLQNVHP NVLAKHLHRT
VLYRDKDVVI LNKPYGVPVR EESGVTTITS VLPVLCKMLD GLKTKTDTEL LPCLGLEKDS
SGALLLARSE AVLEHILSLS RSNQVERKYW VITVGVPVPS EGLIDIPIIE REVTGPKPHF
KMTLSPLFRM NEAGDGMTKV RSHRQAHAAA TKYRVLDSSY GCSLVELQPL TGVKHQMRVH
MAYALACPIL GDHKYSHWSK LAPQKLPDRV LKKLGLEQSK SRYLPLHLHA RQLALPGRSQ
SDVAVSCPMP KYFIKTLNRL QLTFPEDKND E
//
