UniProt: A0A3B3UKW1

Database: UniProt
Entry: A0A3B3UKW1_9TELE

LinkDB:  A0A3B3UKW1_9TELE 
Original site:  A0A3B3UKW1_9TELE

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Ontology (3)   
   GO (3)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (22)   
   InterPro (11)   
   Pfam (4)   
   PROSITE (4)   
   SMART (3)   
All databases (28)   

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ID   A0A3B3UKW1_9TELE        Unreviewed;      3231 AA.
AC   A0A3B3UKW1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Polycystin-1-like {ECO:0000313|Ensembl:ENSPLAP00000013307.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000013307.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000013307.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polycystin family.
CC       {ECO:0000256|ARBA:ARBA00007200}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR   STRING; 48699.ENSPLAP00000013307; -.
DR   Ensembl; ENSPLAT00000029894.1; ENSPLAP00000013307.1; ENSPLAG00000016920.1.
DR   GeneTree; ENSGT00940000167012; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProt.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001822; P:kidney development; IEA:InterPro.
DR   CDD; cd00146; PKD; 10.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000434; PC1.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR002859; PKD/REJ-like.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR006228; Polycystin_cat.
DR   InterPro; IPR014010; REJ_dom.
DR   NCBIfam; TIGR00864; PCC; 1.
DR   PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR   PANTHER; PTHR46730:SF3; POLYCYSTIN-1; 1.
DR   Pfam; PF00801; PKD; 9.
DR   Pfam; PF18911; PKD_4; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF02010; REJ; 1.
DR   PRINTS; PR00500; POLYCYSTIN1.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00308; LH2; 1.
DR   SMART; SM00089; PKD; 12.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   SUPFAM; SSF49299; PKD domain; 9.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50093; PKD; 8.
DR   PROSITE; PS50095; PLAT; 1.
DR   PROSITE; PS51111; REJ; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        2703..2723
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2909..2930
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2950..2972
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          604..675
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          699..765
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          786..832
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          861..920
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          957..1022
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          1041..1106
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          1312..1372
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          1650..1707
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          1710..2462
FT                   /note="REJ"
FT                   /evidence="ECO:0000259|PROSITE:PS51111"
FT   DOMAIN          2746..2861
FT                   /note="PLAT"
FT                   /evidence="ECO:0000259|PROSITE:PS50095"
FT   REGION          2342..2361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3020..3046
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3207..3231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2342..2360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3211..3231
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3231 AA;  356562 MW;  0AD05D5E080CE11E CRC64;
     GKLLWVNGSE AQDGEEGQQP RSSISGGNVC VSFDQSGQTS SHLCDSKRAY VCQYNPHVRV
     PDAGVYLLGM AVFPSDHPLF HLPATLLSAP QSLSSVIEML MFPVMSFVQA GRLSSLEIIV
     QEQSSTVHIR FQTYRPKCPG QHLLLPSCGG PACSPVAVCV PSQTLIKDSP SCPPAQQWCP
     FQGRCLVLSQ PCHPSSCTNC TRGHHLPPGT SRPQYTLKNE IVFTLSSGPA HQLEDILVSP
     GDVIALQHDG GPSALLHCQS SQQSPWRQPV LALNLSEWFW MNDTRQSADL PDLNVENFIR
     NGEGGWLEEE SCCIRVLYVG QNRTQLQGAQ LSAGLPQPGL YSLLVSTTEP SYPSSASCPL
     RVVPPLGLTI LHPPLNNGTV YMQPNDTRLV LSVQSPYETR VSRRGSSVSV AFQSKCPAEV
     LSSPAVCDTG WKSGSAAEAC EPVLYAVLDL SLGEEEQRGQ VQVELEAHNN VTEATLPLVV
     HLEDPLEGLV VQPDPEHRVL MESVVSYTAS VLKGSNPTFK WTVDDKPYFT YFNSVLNVIY
     QNAAIYKLTV TASNHVSTLT KHFNITVDRL QPMANLTVKG VPDVVPQGSN QTLTTSVLVD
     MSVPATFRWS FGDGGYEEFE AKPPYSPSLL CKDSPNQVLL SKNITYIYSQ PGIYTAQVSV
     SNRYDNISQS INMSVYSILT HVDIQTERQF VLLGQSSFFE AHPLPSPYGI HYDWNFGDGT
     ALKGRRVPHT FAQSGNFNVC VSVNNTISFT STCAEIFVYE EIEGLTAKSS SPTELQSPTK
     VWAQLSSGNN ITWIFSMGDG TDPIITSQPN ISHNYVKEGN YTVNVTAMNA VSFGWMPLSV
     HVYVFQVIRM EPSGCVQERT KVNFQAWVSG NATIHHYNWS FGDGSPNETV QGNSSVSHTY
     QQNGNYHLSL LLSSGVNKAT KANFFNWVCV QPAVTNVSIF PEKSHYAVGE EVHLKVTAEP
     EFNYSYQWDF GKGEDPFFTH GSGNVAKYKK SGHYVITVHV FNNISANNAS VAIDVLVPIG
     PILIRHNGTK HNNLTRGAPY TFTSSSLASD VTYTWSFGDE QVLTGQSILI TFNISGKYNI
     TLKAANSVSQ NETFLLVSVF APILRLKVNA SLVNVPLNDS VDFEAYKEDG DSVDYSWILC
     DRCTPIPGTN KMFYTFRSIG TFNIIVIAKN GVGTANASIS LFVQRKLEGL QILAEDIKGG
     GSAALESCCY ATNSVLHLQA GLKEGTNMTF SWNVVREQDT VSSFNTSGKM VELNFSKPGP
     CNIFLRAENL LGHLLVNKTI YFFEPPSGVD LKISNNPVAT GASTNLTVEV MTGSDLQYRW
     SVNGKNQPST EPWLAYTFDS PGRKEVSVEV FNKVRSTNKS KTVDVQDIIS GLSFSRSDDN
     NRNHVETGVG IKLEGEVKTG TDVRWTWLVE GTTKSERQTF LNFSEPKTVT VTLNATNDVS
     TEAFSREFFF QDRIKVELKA SKDYAAVNEK VEFTPLLIGG TNVSLTLTFS PDAEINPEPN
     KTYTHAFSKV YTYYVNLQGC NKVSCHNYKL HIEVVEPVSG LSIQGVTKAI SVGETKSYTA
     NIEKGDPVSF VWTFDLNQKK DTVVGKQVHF TADKPGLLII FLRAVNNVQD QNITEYIQVQ
     NRMSSAELYA VPQDTFVNKT ITLMAHTTPT SSPVDCLWDF GDGSVRVATK TTATTVRYSH
     PGNYLVQVNC SNLVSLVLAE VEVNIRVLEC EEPEVQISQS RLVVWRSQPI SVEASMDLKG
     CVRYGVQYLW QVFSKLTCED KLMKERPLPP APESRFPPSR AVRLPVEVDV RRLQLQLPKM
     ALAAGNYCLV FSLSYEGVPL RKAACLQLSI MTAKLKPIIE GGTRRVWSRT RDLQLSAEQS
     YDPNMDLDNQ SLLRYLWECE STSKGPEHCS SLHFSLGTDP VLGVSGSELE AGVEYTFKLT
     ISKDGMAPES TTQTVLVQSG DIPMVYLECV SCKAQSIYEV SQNSFVSLKG TCTNCQGSQR
     GRWSAMTLHN ETLVLDSSST TTGSDGMNLV LRQGVLRDKD SYIFTLHVTD SSLDGEGAAS
     IILHHNMPPE GGECHLTGAG EAGVLYGDGD GWRIRTLLDQ VHFNCSGYSD LGVSEIPFLY
     SLLVTRCRED YCEDFCIYKG SNPEHSAFLP PGFRSARHRV SVSITVEDHQ GAANLALNKT
     IEVVLPDLPP EYSSLPHWLS EITDSKLKRL LEQGDSQRVR ELSLALITVL NEYEQTRESS
     RVSRDERDYR VRVRSNITRA LTALDLNTVS DIQQTSAALA QCTAVSREFI CEECQNSTLN
     KLESMLEILQ TDTKQGTVPP TEIADNILNI MGDLIHQVSQ SASHFNFQPG YVDTPSPFST
     FSSSSSSSVD HDNTLMDAPS SSLDPHPLRV AAKAYSLSSV LMLILMHARV LNEEPLILRG
     AEIAATGKLA DPQSLLCYHE CERFSIPRAF NQSLGRAAVG NSILQLLFQV ESNPFPFNYI
     SNYAVSTEVA SMEFRTENGT HIPISGLDDS MAITVAISNS SSSGEAGAEG PGVAGVPSAT
     AVNVSRCDSV VVKVSAGNGN RQAGLFVQLN FTAIECEQRL TEEPYLTAYL HSHEEPNEFN
     CTDRKRITLS MTRGHDHRKY TFFLSPESYD TTQDYFINVS TPCGPDSQPA RVRLEVGVFA
     ALCQYFSEAE KQWRTDGMVP LAETNFSRTV CRTRHLTSFA AGLFVPTNAI SFITPERSGP
     PSLIVLLVCI LGLLSYVVAA AILHKLDQLD LRRAGVVPLC GQNGSFKYEI QVKTGWSRGA
     GTTAHVGISL YGRECRSGHH HLDSKGAFTR NALDIFHIAT DTSLGSVWKI RIWHDNKGLS
     PAWRPQYVLV KDLQTESSYY FLVEEWLSVD NERTGGRVEI EVEATEEAAL RRLPRLLRSE
     LQRALCESHL WLSLWERPPR SPFTRLQRAT CCAVLLQLIL LANTLWYSII VDKRYSQRAV
     SHHSSLSGET LAAGVVACLT VYPLYLLVFT VFRMSRSKSV TVEQVSSQVD QESVEIDDLL
     EDSMGGSSFL FFNGETNSEE TYVDLPSPSI KSEDTWDMPE EDTDDRDWPE LMSEESVMGG
     AGHGAGMPRL KRVKGSRYLG DDMTLNPEED EGSDPQYTKH FTSSDEDLIK HILEDGQNFF
     PQADESEMAD LSSIFGDKTE VILLQKLSEP LTLESIRRDP PKTAFTSNTG LFRKVCVTLT
     PLYLWKITSI SELKRLIVIR GTARNLGPHN KKLVPPPPPP PPPRGGPSYC F
//

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