ID   A0A3B3UMU4_9TELE        Unreviewed;       988 AA.
AC   A0A3B3UMU4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Proto-oncogene DBL-like {ECO:0000313|Ensembl:ENSPLAP00000014012.1};
GN   Name=MCF2 {ECO:0000313|Ensembl:ENSPLAP00000014012.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000014012.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000014012.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_014878377.1; XM_015022891.1.
DR   AlphaFoldDB; A0A3B3UMU4; -.
DR   STRING; 48699.ENSPLAP00000014012; -.
DR   Ensembl; ENSPLAT00000022185.1; ENSPLAP00000014012.1; ENSPLAG00000017598.1.
DR   GeneID; 106940208; -.
DR   GeneTree; ENSGT00940000156974; -.
DR   OrthoDB; 4244290at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22826:SF207; PROTO-ONCOGENE DBL-LIKE ISOFORM X1; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          521..701
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          713..831
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          847..887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   988 AA;  113475 MW;  8DD6E6A3C07ADC7C CRC64;
     MAESNMRWGF PRLRRAATSF PGNLHLVLVL RPTSLLSSTP SPSSSTDLGF RFSQDDFLLK
     MPVVMLRSVG DLLRYIDENH LASDFTAKVE YCQSDWVLLR SSIETFAVTV KEIAQLLQGF
     GSELSETELP DEANAIEFLL HSHSHRYRQM KDDIRGVLKE GRLLLSNLET VKAAKREVEE
     EREIQADMET VQRLLAQLRD MEEAFDGFFE KHHLKLQQYL QLLHYESSFQ QMDEVLERIS
     AQEKEIACVG TTVVQTEQLL KDLDSLDKRA QEEMNRAQVV ILHGHQLAAN HHYALALIVQ
     RCNELRHHCD VISTAIRTKR ASLTRTRDLL RRLEEALRWC DEGAYLLASQ MVDKFQTKEG
     AQEALQYLSS HQERAPSVVK NTQDTLSLEF EAVLTPQLQS QITMVKEKLS SVQCMIRNRE
     QCLKKLADVQ VRPIQLVAPR PEPDQAVLRC KSPLFSPKHG VDFNVLNSKF SFDLLPGKRA
     TRRNNSPRKI EVMHDYQGNR SYLYGPNPET DSEAEDNPEQ VTRHIMKELI ATERIYVDEL
     LSVLLGYRAE MEDPSMSYLL PSALRYQKDV LFGNMPEIYQ FHSRIFLHDL QACLETPERV
     GACFLQRKDK FQVYERYCQN KPCSELLWRQ CSDSPFFQEC QKKLDHKLGL DSYLLKPIQR
     LTKYQLLLKE LWKHCVEERY RCELQEALDS MLELLKSVND SMHQIAITGY PGDISQLGRI
     ILQGSFSVWI SHKRAAVRMK ELARFKPMQR HLFLYDHALL FCKRRDEDSH DSFYSFKSCL
     RMSTVVITET VKGDVKKFEI CYSGREVVYL VQAPTVEVKV TWLNEIQKIL ANPQKLRQDE
     DSSLALPDNL LSDSSSATSH AHKYRGEEST HSSPAHSDPV VHSPRRSWPA PAHSVAICEG
     LEDWGATDLS ALSDSDEEDQ PSPLVAGRYR VMVESSMASS DDIIFNCGDV IQLLYEDSSG
     VWMVKNISRG EEGRVQPKDL HRILGESC
//