ID A0A3B3UQD4_9TELE Unreviewed; 340 AA.
AC A0A3B3UQD4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein 1 {ECO:0000256|ARBA:ARBA00040633};
GN Name=HEY1 {ECO:0000313|Ensembl:ENSPLAP00000014912.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000014912.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000014912.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000256|ARBA:ARBA00038262}.
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DR RefSeq; XP_014877826.1; XM_015022340.1.
DR AlphaFoldDB; A0A3B3UQD4; -.
DR STRING; 48699.ENSPLAP00000014912; -.
DR Ensembl; ENSPLAT00000023398.1; ENSPLAP00000014912.1; ENSPLAG00000018734.1.
DR GeneID; 106939795; -.
DR KEGG; plai:106939795; -.
DR GeneTree; ENSGT00940000157068; -.
DR OrthoDB; 5405528at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF78; HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 3: Inferred from homology;
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 77..132
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 154..186
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 37..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 36705 MW; 5B3F7B97D940F7DF CRC64;
MFKLLLGPCA AAALCETKRA FIRVSLDIRM KRSLNYSSSD SELDDNVEVE KDSGDENGQA
DSPGSMSPST TTTQVQARKR RRGIIEKRRR DRINNSLSEL RRLVPSAFEK QGSAKLEKAE
ILQMTVDHLK MLHASGGKGY FEAHALAKDY RSLGFRECLA ETARYLSIIE GRDSTDSLRV
RLVSHLSNYA SQREVHTGLE HFAWGSAYGT APSPLPHHLL LQHPQGRTPA PRTNSSPPSS
CSSSSSSSSS SGEASGASRL SMLSPTESLR VPPNGSLALS LPVPTSKLSP PLVSSLSSLS
AFPLSFGAFP LISPTAIGTV SPTSTMSKPY RPWGMEIGAF
//
