ID   A0A3B3USM9_9TELE        Unreviewed;       654 AA.
AC   A0A3B3USM9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=THO complex 1 {ECO:0000313|Ensembl:ENSPLAP00000015672.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000015672.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000015672.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_014890075.1; XM_015034589.1.
DR   STRING; 48699.ENSPLAP00000015672; -.
DR   Ensembl; ENSPLAT00000024404.1; ENSPLAP00000015672.1; ENSPLAG00000019648.1.
DR   Ensembl; ENSPLAT00000024408.1; ENSPLAP00000029443.1; ENSPLAG00000019648.1.
DR   GeneID; 106948746; -.
DR   KEGG; plai:106948746; -.
DR   CTD; 9984; -.
DR   GeneTree; ENSGT00390000016232; -.
DR   OrthoDB; 5490969at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR021861; THO_THOC1.
DR   PANTHER; PTHR13265; THO COMPLEX SUBUNIT 1; 1.
DR   PANTHER; PTHR13265:SF2; THO COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF11957; efThoc1; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          572..654
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          193..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  74970 MW;  AAEE6270EE458C60 CRC64;
     MSPPVFNFVD VKEKFTAAAR QALSGKTCKH LITVFSQISG NETEKKTTLD QALRGVLGDQ
     IIEQKMSCDD YLSLIYLSID AVTEGICSAT IPFVLLGDVL DCLPLDLCDK IFSFVEKNVS
     TWKSSSFYTA GKNYLLRMCN DLLRRLSKSQ NTVFCGRIQL FLARLFPLSE KSGLNLQSQF
     NLDNITVFNK NEQESTLGQK QTDEKEDTME VEEGEMGEDD APAPCSIPID YNLYRKFWTL
     QDYFRNPVQC YDKFSWMTFL KFSDETLAVF KSFKLDDMQA SKRKMEDLRA SDGEHVYFAK
     FLTSEKLMDL QLSDSNFRRH ILLQYLILFQ YLKGQVKFKS SSCILNDDQS AWIEETTKLV
     YQLLRETPPE GEQFATMVEH ILNTEENWNS WKNEGCPSFV KERTSDDKPK RPTRKRQAPE
     DFLGKGPERK IFMGNDELTR LWNLNQDNME ACKSESREFM PSLDEFFAEA IEQADPVNMV
     EEEYKVVRNP NYGWRALRLL SRRSPHFFQP TNQKFKSLAD YLDTMVCKLA KELPKDIPSE
     EIKTGEEDDD DNGDNLLKDS NDSPSIQSKT VTNHQMDDIA AKLGSQWKTL ASHLEMKAAE
     MREIETDSED VDVQAKLLLV AWQEREGSQA TVENLATALS AAGFSQLAER LSEA
//