ID A0A3B3UV67_9TELE Unreviewed; 582 AA.
AC A0A3B3UV67;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Protein numb homolog {ECO:0000256|PIRNR:PIRNR017607};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000016566.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000016566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR017607};
CC Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR017607};
CC Cytoplasmic side {ECO:0000256|PIRNR:PIRNR017607}.
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DR AlphaFoldDB; A0A3B3UV67; -.
DR Ensembl; ENSPLAT00000025563.1; ENSPLAP00000016566.1; ENSPLAG00000020788.1.
DR GeneTree; ENSGT00940000156005; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF5; PROTEIN NUMB HOMOLOG; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607}; Membrane {ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 37..173
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 211..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..349
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 63481 MW; 2B8AE53C2D7E32AE CRC64;
MNKLRQSFRR KKDIYVPESS RPHQWQTDEE AVRSGRCSFA VKYLGHVEVE ESRGMHICED
AVKRLKTDRK FFKGFFVKAG KKAVRAVLWV SADGLRVVDD KTKDLILDQT IEKVSFCAPD
RNFERAFSYI CRDGTTRRWI CHCFMAIKDS GERLSHAVGC AFAACLERKQ KREKECGVTA
TFDANRTTFT REGSFRVTTA TEAAEREEVM RQLQDAKKGS GSSPSPSSSP PLSVAALGPQ
VIPRRHAPAE ALARQGSFRG FPALSQKTSP FKRQLSLRMN ELPSTMQRKS DFPIKNTVPE
VEGENDSISS LCTQIATAFS GPPEDPFSSA PMPKPTSSPQ SPVAPGKTSP PTASPAMSAH
KRTPSEADRW LEEVTKSVRV PQSKPMAAGG TPPPQPFAAP VHIPMAPVPV VPTVPFMPSL
TPPVPMVPPR QPAFQPPAPA SYPVSNGLPF PQPSVPVFGI TPSQMVANVF GSATQPQPFL
IPAVATMPQT GDAQAINNVS PYIKAPAPTE VHIQPPNGRA AFNGADGWAA SSSQYGQPAP
AQQEDAFEAQ WAALENRPHQ RTTPSPTNPF STELHKTFEI QL
//
