ID A0A3B3UXH9_9TELE Unreviewed; 1743 AA.
AC A0A3B3UXH9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Pappalysin 2 {ECO:0000313|Ensembl:ENSPLAP00000017397.1};
GN Name=PAPPA2 {ECO:0000313|Ensembl:ENSPLAP00000017397.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000017397.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000017397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSPLAT00000031432.1; ENSPLAP00000017397.1; ENSPLAG00000022051.1.
DR GeneTree; ENSGT00940000158543; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0008593; P:regulation of Notch signaling pathway; IEA:Ensembl.
DR CDD; cd00033; CCP; 3.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF1; PAPPALYSIN-2; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 3.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50923; SUSHI; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1743
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017389656"
FT DOMAIN 1505..1574
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1575..1630
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 62..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1743 AA; 193331 MW; 3CF4F61558F776BC CRC64;
MLLIRLLPIF LVVITNTWLL SPVRSDTLSR HKRSLARRAD SELSRTAAGE PCFVSPSRLK
PRVLSPTQHR PPAALPRTST SRRAPFTVKG AREVCPGGCG LDTELREVSA ARREHEGRGG
TGDLAERVGG YPTLFDRFYV NNIRNDERES NYVGEDAPHP PGRSGVKDTE ERVSQSSRSR
VSRSLEAKKL RYGKEGNFRG EKVPPESSTV HRGLQVLHRL RQDVGDGDNQ SSTMTVADAV
ATEDYSGEVE EADAAMDSPN NSWGTPLPRV PPSWMTALYF NGHREQLKVK LAEGVELPRD
KFSLELWVKP EGGQSNPAVI AGLFDNCSHS LSEKGWSVGI RTMEPAGTKD ARIYFTLRTD
RAVKSTTISS HQRYRANAWT HLMATYNGHN MTLYVDGAKV SSELADSGDL YSPFMQTCRT
LFLGSKQSDL GQSFRGHIGG VVLWGYARSH QDLLKPPLQI DLNEPVLAMW ADFTNVNSLF
LLYFTPEQEL VSSFLPPLCG QTQCDNTDII SGYNNNWQLR TPKRIRYRIV NLSEDDGGNP
TVTPEQIQVQ HQALCEAFQP YNITLELSVH TVKNSSLRQR FILSNCRIGK IGNRQCDPEC
DHPRTGHDGG DCLRLGHCYN WKRQDGVCDM ECNTIKFEYD DGDCCDPDVT DVRKTCFDPE
SPDRAYMSVK ELKDELDLSG SDTLNVFFAS NSMREELAGA ATWPWAKEAL THQGGMVLNP
SYFGTKGHQN TMIHEMGHIF GLYHVFKGVS ERDSCDDPCQ ETIPSMETGD LCADTAPTTK
SKTCHDPEAV NDTCGFSIYH NTPYSNYMSY TDDNCTNHFT PNQVARMHCY LDLVYQKWLM
DSRPAPVPLP PMVTGQSTNS VSIYWLPPMR GSLFQSSSFR VPGIDCGNCE KDGVFHQYAF
QASSPRICDT SGYWTPEEAV GPPDVEQACE PSLQAWSPEL SLYDANVTSP CPETEGCTLT
LRFLHPVVPH GLTLWVTYTS TKNVFLFFNL LYNWKCIHLG PQHVFCDMPL TLRLDTNNAA
ISAVKLSTFD EKMEIDAAML SSGPSSSLCS GCQPVQYRIQ RQPPFTSKSP PPQMGQTFTD
SSVTQGVKYQ YTIQVETGRL LSFPSPPLVY TPGQTYCGDG AIQGSVLAEE CDDSNLLDGD
GCTKKCLKET GFNCVGEPSQ CYVFDGDGVC EEFERGSSVQ DCGYFTPLGY TDQWASSASA
SHQDPKRCPA VAATGEPSLP KLCSFQHLEV NDKHSDAWFP CTAQSDTNNG LEHSYWIKVG
FLHPGVAASV MVYMASDGSL SGEPWRRTVT ILLSDANGKN HSLGTHVPSC YRNPLVVNVT
HDLSQPFFLT STVIILFSSP SMAVRAVALR TSCHFSTFAL TGCASEGGCL RQPCQIDSCS
PPQLKHASIR CTGGGEASSC SVKCHRGYKQ FSSFFIAFFL HFQRTIELDC FRGSWDRVVS
CEPVDCGLPD QSHVYHAIFS CPWGTTFAKQ CSFTCGPPAI LQGDSDRLVC LEDGLWSFPE
AYCKIECPEA PNIPSARLLT KDCLASGHDV GSFCRYRCSP GFYVVGSLKK KKPKLYFKLE
CLEDGQWEEN ACEPISCPPL PDVFQGMYTC TNGLRYNTRC TLQCPDATEN SEIRCTKDGK
WTAEFTMCST LQGSCSAPPN LNYIEYSCDQ GMNIGESNQI LKLQSIICTG MMKWYPDPEN
IHCIQSCEPF GGDGWCDTIN NRAYCQYDGG DCCSSTLSTR KVSISLPFNA VRFQRVCSCR
HNK
//
