ID A0A3B3V0H0_9TELE Unreviewed; 3356 AA.
AC A0A3B3V0H0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Low-density lipoprotein receptor-related protein 1-like {ECO:0000313|Ensembl:ENSPLAP00000018452.1};
GN Name=LRP1 {ECO:0000313|Ensembl:ENSPLAP00000018452.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000018452.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000018452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR STRING; 48699.ENSPLAP00000018452; -.
DR Ensembl; ENSPLAT00000027947.1; ENSPLAP00000018452.1; ENSPLAG00000023251.1.
DR GeneTree; ENSGT00940000157899; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:1901342; P:regulation of vasculature development; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 20.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 20.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 7.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00057; Ldl_recept_a; 20.
DR Pfam; PF00058; Ldl_recept_b; 15.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 20.
DR SMART; SM00135; LY; 32.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 19.
DR SUPFAM; SSF63825; YWTD domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 10.
DR PROSITE; PS50068; LDLRA_2; 20.
DR PROSITE; PS51120; LDLRB; 19.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 64..79
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 226..269
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 270..313
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 462..504
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 505..550
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 551..601
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1194..1238
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1239..1281
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1282..1328
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1510..1552
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1597..1636
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1792..1834
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1835..1877
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1878..1921
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2201..2245
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2246..2288
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2800..2815
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 2904..2948
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2949..2991
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2992..3035
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3036..3078
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 740..752
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 747..765
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 781..793
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 788..806
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 822..834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 829..847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 870..888
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 882..897
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 901..913
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 908..926
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 968..983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1011..1026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1052..1067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2389..2407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2423..2435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2430..2448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2442..2457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2462..2474
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2469..2487
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2568..2580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2575..2593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2587..2602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2661..2679
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2694..2706
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2740..2752
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2747..2765
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2759..2774
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3169..3181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3176..3194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3209..3221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3216..3234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3228..3243
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3268..3283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 3356 AA; 376792 MW; 7E24CDFF568BFB09 CRC64;
EKAPECAAFG CEFLCGVTHD GPRCYCRTGY EVAADGKKCK DFNECSVYGT CSQTCTNTEG
GYTCSCVEGY LLQPDNRSCK AKNEPVDRLP VLLIANLHGI RCTSLSGSAS RLSVPHTNQT
MAMDFIYAEE TVCWIDVGDS PAATQLKCTS IQDLKANSTS IRPVNITLSL HHVEQMAIDW
LTGNFYFVDD VDDRVFVCNK NGQTCVTLLD QELHNPKGIA LDPAMGKLFF TDYGSTPRVE
RCDMDGQNRT KLVDSKIVFP HGITLDLVNR LVYWADAYLD YIEVVDYEGK NRHTIIQGLL
IEHLYGLTVF ENYLYATNSE EGNLNPKTSV IRVNRFNSSD FQVVTRLDRG AALHVYHQRR
QPQVRSHACA LDQFGKPGSC SDICLLSNSH KTRTCRCRSG FSLGSDGKSC KKPEHELFLV
YGKGRPGIIR GMDMNAKVPD EYMIPIENLM NPRALDFHAA SEFIYFADAT SYIIGRQKID
GTERDTILKD GIHTVEGIAV DWIGGNLYWT DDGPKKTISV ARLEKASQTR RTLIEGKMSH
PRAIVVDPQH GWMYWTDWEE DPTESNRGKI KKAWMDGSHH QVFLTSKTVL WPNGLSLDIP
QGILYWVDAY YDRIEMVFLN TTERKVVYEG EELNHAFGLC HHGKFLFWNE YRGGSIYKLD
QETKTVTLLR NERPPIFEIR VYDAHLQQGT NKCRINNGGC SSLCLAIPHG RSCSCADDQI
LDVDNVTCKA NPSYVPPPQC QPGEFACKNN RCIQERWKCD GDNDCLDNSD EAPDLCHQHT
CPADRFKCQN NRCIPLRWLC DGDNDCGNDE DESNTTCSAR TCPPNQFLCA SSRCIPISWT
CDLDDDCGDR SDEPDSCAYP TCFPLTQFTC ANGRCININW RCDNDNDCGD NSDEAGCSHS
CSSVQFKCNS GRCIPEYWTC DGDNDCGDYS DETHANCTIR EPRPAGGCHA DEFQCRMDGL
CIPMRWRCDG DTDCMDLSDE NNCDGWNHTC DTAVKFSCRD SARCISKAWV CDGDSDCEDN
SDEDNCEALV CKLSHHMCAT NDSICLPAEK LCDGTDDCPD GSDEKLCDLC SVDNGGCSHN
CSIIPGEGFM CSCPLGMELG ADNKTCQIQS FCAKHLKCSQ KCEQEKSRVK CSCYDGWELE
ADMESCKSTD PFKPFIIFSN RHEIRRIDLH KGEFSVLVPG LRNTIALDFH LNQSTLYWTD
VVEDKIYRGK LSENGGDFEV VIQYGLATPE GLAVDWIAGN IYWVESNLDQ IEVAKLDGTM
RTTLLAGEVE HPRAIALDPR DGILFWTDWD ASLPRIEAAS MSGEGRRTIH RETGSGGWPN
GLTVDYMERR IVWIDARSDA IYSAMYDGSG LIEVLRGHEY LSHPFAVTMY GGEVYWTDWR
TNTLAKANKW TGHNVTVVQR TNTQPFDLQV YHPSRQPLAP NPCATSDGKG PCSHLCLINF
NQTFSCACPH LMKLQADKRT CKESRKFLLY ARQIEIRGVD IDNPYYNYII SFTVPDIDNV
TVVDYDAVEH RIYWSDVRTQ TIKRAFINGT GVETVVSADL PNAHGLAVDW VSRNLFWTSY
DANKKQINVA RLDGSFKNAV IQGLDKPHCL VVHPLLGKLY WTDGDNISMA NMDGSNHTLL
FTNQKGPVGL SIDYETKQLY WISSGNSTIN RCKLDGSKLE ILEGVKGKLN KATALAIMDK
LWWADQGADQ IGTCDKTDGG NWKVLRNNTS PMMHMRIHDE DVQKGKKYLT KVGIRPTIMA
TARPACMGSF LLYSVHEGIR GIPLDPADKS DALVPVSGTS LAVGIDFHAE NDTIYWVDMG
LSTISRAKRD QTWREDVVTN GIGRVEGITV DWIAGNIYWT DQGFDVIEVA RLNGSFRYVV
ISQGLDKPRA ITVHPVKGYL FWTEWGQYPR IERSRLDGSQ RLVIVNVSIS WPNGISIDYE
EGLLYWCDAR TDKIERINLE TGENRELVLA SNNMDMFAVS VFEGYIYWSD RTHANGSIKR
GSKDNATDAV QLRTGIGVQL KDIKVFNRAR QQGTNVCKEK NGGCEQLCLY RGNGERTCAC
AHGMLAEDRR SCRDYDGYLL YSERTILKSI HLSDETNLNA PIKPFEDPEH MKNVIALSFD
YHGGGGKGAN RIFFSDIHFG NIQQINDDGS DRKIVVDNVG SVEGLAYHRG WDTLYWTSYT
TSTITRHTVD QSRSVAYNRN TVVTMSGEDH PRAFVLDECQ DLMFWTNWNE QSPSIMRASL
NGANVLVIIG SDIKTPNGLA IDHRAEKLYF SDATLDKIER CEYDGSNRYV LLKNEPVHPF
GLAVYGDYIF WTDWVRRAVL RADKFTGGDM KVLRADIPQQ PMGIIAVAND TNSCEYSPCR
TNNGGCQDLC LPTSDGRVNC SCRGDRQLLE DNTCSSLNMS CGSVDDFECG NGDCINYSLT
CDGMAHCKDK SDEKQSYCAN RICKKGYRRC LNGRCLGHQF WCDGTDDCGD NSDEVPCNMT
LCKAGEFQCK DGSCISNHTR CDQVVNCEDA SDEMNSITSW DFSEFKNMKL KKVLFPQSLP
TVRVSSAWEL KAPPSGAVRK QRCVICPRGC VTATMTAETF PMRETLKCPV NFFACPSGRC
IPMSWTCDKE NDCENGADET HCGQSLCANP DVFQCPGSHV CVPQRWKCDG DNDCPDGADE
SVKAGCMYTN NTCDTKNEFM CQNRQCIPKH FVCDHDIDCS DGSDESPECE YPPCGPEEFR
CANGRCLNQK KWECDGEFDC PDHSDEAPKN PNCVDSERIC NESSFVCHNK KCLNETLLCD
RNDDCGDGSD ERNCFINECL NSKLSGCSQL CDDLKIGFKC RCHPGFQLKR NGKTCVDIDE
CTTTYPCSQH CLNTHGSFHC LCVDGFEVSP NDPTICKSTS EVEPYLIFAN RYYLRKLNLD
GSNYTLIKQG LNNAVALDFH YAEQMIYWTD VTTQGSMIRR MQMNGTNMEV LHRTSLSNPD
GLAVDWVGGN LYWCDKGRDT IEVSKLNGAY RTVLVNSGLR EPRAVAVDVR YGYLYWSDWG
DNPHIGRIGM DGTDRKIIIE DKITWPNGLT LDFVNDRIYW ADAREDYIEF ASLDGTSRHT
VLNHDIPHIF AMTLFEEYIY WTDWETKSIN RAHKTMGTNK TTLINTLHRP MDIHIYHPYR
QPPVLKHPCQ TDNGGCSNLC LLSPGGGYKC ACPTNFYLAS DQRTCMSNCT ASQFVCKNDK
CIPFWWKCDT EDDCGDGSDE PSDCPDFKCR PGQFQCGTGI CTNPAYICDG DNDCQDFSDE
ANCDIHVCLP SQFKCSHPNR CIPGIFRCNG QENCGEGEDE KDCPEVTCAP TQFQCAMTKR
CIPRLWVCDR DNDCADGSDE PANCSKFTDR RRSLRRAFCE CRSPSCPNAR LPPQLK
//
