ID A0A3B3V156_9TELE Unreviewed; 560 AA.
AC A0A3B3V156;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Perforin 1.2 {ECO:0008006|Google:ProtNLM};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000018672.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000018672.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3B3V156; -.
DR Ensembl; ENSPLAT00000028233.1; ENSPLAP00000018672.1; ENSPLAG00000023786.1.
DR GeneTree; ENSGT00530000063725; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096:SF5; PERFORIN 1.3-RELATED; 1.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 15..358
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 380..497
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 560 AA; 62379 MW; 0819ECC00FE83E5B CRC64;
FWRGFPVSVS SFIGSPKQCE TAHFVPGYNL GGEGYDIVTM ERKGAYVIDT ETWDLGNGTC
KMYRNRYQNG ENQKVPVSVV DWRNLPKCSM KVSSMLYDSV ESLVNDSTSS VSNDWKIGLE
IPVDPSVTVG VGLGGSHSRA SEFGMKKSKS DRYEFVRQSV NCNFYRYRLT TSPPLSHDFL
AAVNSLPPYC PGKASPYRDL IDTYGTHYIT QVYLGGEIKA TTSFQTCKAT MNGFTATDVS
DCLTVEASAS FANSASVKAM TKHCEDKKKK LNSGQSFSSE FNERFTEVTG GDEMEVALFG
GGSDPDVYKN WLNSLKTIPD IVQYNLKPLH TILPDNHRAK KGLKKEVEQY ILKNAVLKKC
SESCQIGHRS NKRDPCACVC NSNKNVKANC CPGGKGLATL KVYKLYARGL YGDTFGKTDG
SVEVKYGDQL KRTKIISNDD NPRWPEKFDF GPIVINMQNK LTFSVYDEDT RWNSDLLGKC
SFDLRKANVS DSCMFNHGTF FFSYSVECAP SLGGSRCDEY ISSPMDPSLT KEFYTRNGVL
LGNSMKKFFK PTRQAGLDQF
//
