ID   A0A3B3V218_9TELE        Unreviewed;       525 AA.
AC   A0A3B3V218;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=WASP actin nucleation promoting factor {ECO:0000313|Ensembl:ENSPLAP00000018946.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000018946.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000018946.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_014899407.1; XM_015043921.1.
DR   AlphaFoldDB; A0A3B3V218; -.
DR   STRING; 48699.ENSPLAP00000018946; -.
DR   Ensembl; ENSPLAT00000032107.1; ENSPLAP00000018946.1; ENSPLAG00000023747.1.
DR   GeneID; 106954426; -.
DR   CTD; 335158; -.
DR   GeneTree; ENSGT00730000110895; -.
DR   OrthoDB; 3837860at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   CDD; cd00132; CRIB; 1.
DR   CDD; cd01205; EVH1_WASP-like; 1.
DR   Gene3D; 3.90.810.10; CRIB domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR011026; WAS_C.
DR   InterPro; IPR033927; WASPfam_EVH1.
DR   InterPro; IPR000697; WH1/EVH1_dom.
DR   InterPro; IPR003124; WH2_dom.
DR   PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR   PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR   Pfam; PF00786; PBD; 1.
DR   Pfam; PF00568; WH1; 1.
DR   Pfam; PF02205; WH2; 1.
DR   SMART; SM00285; PBD; 1.
DR   SMART; SM00461; WH1; 1.
DR   SMART; SM00246; WH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 2.
DR   PROSITE; PS50108; CRIB; 1.
DR   PROSITE; PS50229; WH1; 1.
DR   PROSITE; PS51082; WH2; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          28..137
FT                   /note="WH1"
FT                   /evidence="ECO:0000259|PROSITE:PS50229"
FT   DOMAIN          221..234
FT                   /note="CRIB"
FT                   /evidence="ECO:0000259|PROSITE:PS50108"
FT   DOMAIN          453..470
FT                   /note="WH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51082"
FT   REGION          137..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..448
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..525
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  55754 MW;  24992BF6028EC644 CRC64;
     MSRGKNKTES VPSSLLSQQE NEKLEELLGR RCASMATAVA QLFMALPNSP SMWSLQHTGV
     VCFVKDNPQR SYFIRMFDLK VGRQIWEQEL YNQLVYSTPL PYFHTFAADD CQVGLNFTDQ
     QEADAFQGTI MEKINQRHNR QEKKQRPPPK NDRGSLPPVP PAASPSSASF HMATVDIQNP
     DIQSSRYRSM PSPAIPPAVS SKGKKNKKDK KKAGKISKAD IGAPSGFKHV THVGWDPNNL
     DPDLSKLLSQ AGISVSDLKD EQTSQMIYNV IEQSGGLEAV KREMNRGDVP PPPPSSRQGP
     LPPVPGPGPP APPPSRGRSG PLPPIPGQAQ RGAPPPQPPP SRGCLPPPPP TSRGGPPPPP
     PPAHSSLPPP PPSSRGSHSM PPPPPPSSQH RSMGVPPPPV PSTPSRGGGG GAPPPPPPPP
     PPPPSAPSDF PPPPKIGGAP PPPPPASSGG GDGRGALLDQ IRLGKSLRKV TESSEPPPPS
     TPEGGEGIVG ALMMVMQKRS KVIHSSDESE EEAGYDDDDD DEWDD
//