ID   A0A3B3V263_9TELE        Unreviewed;       450 AA.
AC   A0A3B3V263;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Protein transport protein Sec61 subunit alpha-like 1 {ECO:0000313|Ensembl:ENSPLAP00000019143.1};
GN   Name=SEC61A1 {ECO:0000313|Ensembl:ENSPLAP00000019143.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000019143.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000019143.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}.
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family.
CC       {ECO:0000256|RuleBase:RU004349}.
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DR   AlphaFoldDB; A0A3B3V263; -.
DR   Ensembl; ENSPLAT00000016765.1; ENSPLAP00000019143.1; ENSPLAG00000001032.1.
DR   GeneTree; ENSGT00390000003721; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   Gene3D; 1.10.3370.10; SecY subunit domain; 1.
DR   InterPro; IPR002208; SecY/SEC61-alpha.
DR   InterPro; IPR023201; SecY_dom_sf.
DR   NCBIfam; TIGR00967; 3a0501s007; 1.
DR   PANTHER; PTHR10906:SF19; PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1; 1.
DR   PANTHER; PTHR10906; SECY/SEC61-ALPHA FAMILY MEMBER; 1.
DR   Pfam; PF00344; SecY; 1.
DR   PIRSF; PIRSF004557; SecY; 1.
DR   SUPFAM; SSF103491; Preprotein translocase SecY subunit; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        418..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   450 AA;  50283 MW;  4F7F0069F8DAA4FF CRC64;
     MGVKFLEVLK PFCAVLPQIQ KPKQKVNIFH LWCYYFHFIE LLFILVYAAS SFCTLMELGI
     SPIFTSRLLM QLLAGAKIIE VLDTPKDRAL FNGAQKLFGI IITFGQAIVH VMTGMYGDPS
     EMGASFCLLL IIQLFVTGLI VLFLDELVQK GYGLGSGIIL FIITIFCETI VWKAFSPTTV
     NTGNNTEYEG AVIALFHLLA TKPDKLDALN EAFFRQNLPN LMNLIATVFV FAVAIYFQGF
     RVDLPIESSR YCDQHYTYSI KLFNTFNIPI ILLSALVSNL YVISHMLSTR FSGNFVVNLL
     GTWSNTTSGS PARVYPVGGL CYYFYPPESF FSVQALIYIF FMLGSCAVFS KSWIEVSGSS
     AEDVAKLLKD QQMVIRGHSE TSMVHELNRY IPTAAAFSGL CCGGLSVMAH FLGAFASGND
     ILVVVIIIYE YFEIFVKEQS EVSRIRALLF
//