ID A0A3B3V4M9_9TELE Unreviewed; 703 AA.
AC A0A3B3V4M9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSPLAP00000020008.1};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSPLAP00000020008.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000020008.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000020008.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3V4M9; -.
DR Ensembl; ENSPLAT00000014616.1; ENSPLAP00000020008.1; ENSPLAG00000002611.1.
DR GeneTree; ENSGT00940000155846; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 14..120
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 130..232
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 233..346
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 404..598
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 703 AA; 81044 MW; B403D1E7B505E241 CRC64;
MFIVHNDLED GWMWVANVRT EEQGLIVEDL VEEVITKTEA YNLLMSVGQV CSFLVRPSDN
TPGDYSLFFR TSENIQRFKI SPTPNNQYMM GGRYYNSLDD IIDHYKKEQI VEGYNLKEPV
SIQVSTRSDC VIKVRSVEKR KGKRWKTLYF ILEGNDAQLI YFESEKRATK PKGLIDLSVC
SVYCVHDSLF GRPNCFQIVV QHFSEEQYIF YFAGEVPEQA QDWMKCLQTF CSNLRKTTVP
TSNKRLRQVS SLVLYVEEAH KLPVKYFTNP YCNIYLNSVQ VAKTQPREGQ NPVFTEEFIF
DDLSSEVNRF EISLGNKTKK NKESDILFMR CQLGRLQKGQ MIDEWFPLSS HVPLKGIEPG
SLRVRHRYSM EKIMPEEEYS EFKEMILQKD FHAIYALANV CGQDRTLLAS LLLRIFRHEK
AEAPLLRTLN DREINMEDEA TTLFRATTLA STLMEQYMKA TATPFVHYAL KDTILKIMES
KQSCELNPSK LEKNEDVSTN LAHLLNILSE LVEKIFMAAD ILPPTLRFIY GCLQKSVQQK
FPSNHTMRTR VVSGFVFLRL ICPAILNPRM FNIIADPPSP TAARTLTLVA KSVQNLANLV
EFGAKEPYME GVNPFIKNNK HRMIMFLDEL GNVPDLPEHP ESFRTDLSRD LAALHEVCAT
HSDELRTLSN ERGAQQHVLK KLLAITELLQ QKQTQYAMSN CNR
//