ID   A0A3B3V5J4_9TELE        Unreviewed;       909 AA.
AC   A0A3B3V5J4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Ras and Rab interactor 2-like {ECO:0000313|Ensembl:ENSPLAP00000020184.1};
GN   Name=RIN2 {ECO:0000313|Ensembl:ENSPLAP00000020184.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000020184.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000020184.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC       {ECO:0000256|ARBA:ARBA00006919}.
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DR   AlphaFoldDB; A0A3B3V5J4; -.
DR   STRING; 48699.ENSPLAP00000020184; -.
DR   Ensembl; ENSPLAT00000014166.1; ENSPLAP00000020184.1; ENSPLAG00000002901.1.
DR   GeneTree; ENSGT00940000154866; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR045046; Vps9-like.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23101:SF51; RAS AND RAB INTERACTOR 2; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF02204; VPS9; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00167; VPS9; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF109993; VPS9 domain; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   3: Inferred from homology;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN          60..152
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          630..770
FT                   /note="VPS9"
FT                   /evidence="ECO:0000259|PROSITE:PS51205"
FT   DOMAIN          800..891
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          190..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..314
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..469
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   909 AA;  101208 MW;  97CB6FA267B7E875 CRC64;
     MVQTAPALDK EPLEIQGLQS GAFLQPPRCR GSVGEWDSGY DSLRRRMSVL ERLTQTHQVW
     LLLAVSEEEA SGILLKQPPG VFLVRKVLQR KVLSVRLDKD QSQNPISHFN VRESQYSFSM
     EGSGISFADL FHLVAFYCVS RDILPFTLKL PEAILSAKTQ KELEEVAQLG AGFWDSALCS
     QRRCSTPPCL RLSRTLSPQR TKRTAEVEES HQSAPPTLQP HTAPPAGFQD AAPPTGPLCF
     VTPLFLQTHS RDPDPPEKAD DSPPLSSSRC AAEPDLDRTK LNGKSRSPPP RPPPPRSAPS
     RRPAPPPPGP PSAVSRTKSM PVAAKRQQPS GRRPAPAPPA LGGRTSSSTK STSNRPPPRP
     QKPDLEAHRC HIALDDETIA KALSRANLPT CQPPLVAEEP PQSLSGPDER GRQRFSDMSM
     STSSSDSLEY SRSPGFSLDL APGPPQHPAE DTSEDDEDVE EEEEEDYGVG MEADLESRLR
     PILKARRRRV GVSLGGGSFV LPRSLKGRFS KVGGMLSSLI TPEKRAVKRI AELSRDKSSY
     FGSLVQDYIS FVQENRSCHT SGMDFLQTVR QFMTQMKAYL RQSSELDPPL ESLIPEDQID
     RVLEKAMHKC VLKPLKSIIE VILHDFQVKS GALQQLRENL ALARNKKPHE LGVDGAVPPD
     SVAIEKIRQK FLNMRKMYSP DQKVSLLLRV CKLIYTIMQD NSGRMFGADD FLPMLTYVVA
     QCDMPQLDTE VQYMMELLDP TLLQGEGGYY LTSAYGAMAL IKNFQEEQAA QVLSSEARNT
     LHQWHRRRTS QRSAPSVDDF QNFLRVALQE VGLGCTAKTL QVQPYTTAEE VCSLCAYKFK
     IPDPENYALF LITEETRQQL AADTHPQQIK AELHSRPLAH VFHFVYRRVD NLNLCIPAHI
     NNGNCLQME
//