ID A0A3B3V610_9TELE Unreviewed; 740 AA.
AC A0A3B3V610;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSPLAP00000020324.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000020324.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000020324.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_014883141.1; XM_015027655.1.
DR AlphaFoldDB; A0A3B3V610; -.
DR Ensembl; ENSPLAT00000013823.1; ENSPLAP00000020324.1; ENSPLAG00000003188.1.
DR GeneID; 106944583; -.
DR KEGG; plai:106944583; -.
DR CTD; 4744; -.
DR GeneTree; ENSGT00940000161685; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}.
FT DOMAIN 59..370
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 13..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..213
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 261..334
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..482
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 84679 MW; 5AC8669A8E3CC365 CRC64;
MSFTVDHHFM GPSSYRKARP ASVSSSGFHS QQRRRLTYSQ PSSIESLETF NGDMTRRSEK
EILQALNDRF AGYIDKVRNL EMHNRNLEAE AAALRQSQAG RISVGEHYER ELNDLRGLLQ
QLTGEKTRAA LEHEHLEEDI QHLQVRLEDE ARNREELEAA ARAMKKYVEE CRLARLELDK
KLRALEEEAS FLKKNHEEEV AELLAQIQGA QVSFDLRDTL KADVTSALRE IRSQLDSHAS
KSAVHAEEWF KVRMERLSDA ARSNQDAIRG SQEEIAEYRR QLQSRTIELE TLRGAKESLE
RQRMESEDRH QDDITSLQET INQLDNELKT TKWEMASQLR DYQELLNVKM ALDIEIAAYR
KLLEGEENRF VSGGSPYTYL ESRISAHVKV KSEEISDTVI VEEQTDETQV TEVTEEADDE
EEEAEEEKKE EEEEEEEAEK EDEETKEDEE GEEVEKEEEG KEEEQKEEEE EEKEEEKEEE
EGEEEKAKSP AEKSPESKSP PKSPESKSPA AKSPAKSPAG DESKSPESKS PAPKTPESKS
PEKESAKPAA AKDTPKEEKK EEKSQPAKEE QKEKEPPVKE EQKQEPKEKE PEKVDKPDAK
KDEKTKEETS KPETPSKPTE DKPAPKPEPK ESSPPAKEEK PAAPKPEKPE PEAKSEKTES
KKEEKKPEEK PEKTESKKEE KKPEEKPAAK VEPEKTESKK EEKKPDEKSK EESKEGAKAE
KAEKSSSTES KETKEEKAKK
//
