ID   A0A3B3V8Z1_9TELE        Unreviewed;      1288 AA.
AC   A0A3B3V8Z1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like {ECO:0000313|Ensembl:ENSPLAP00000021417.1};
GN   Name=SYNGAP1 {ECO:0000313|Ensembl:ENSPLAP00000021417.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000021417.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000021417.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_014913466.1; XM_015057980.1.
DR   STRING; 48699.ENSPLAP00000021417; -.
DR   Ensembl; ENSPLAT00000011040.1; ENSPLAP00000021417.1; ENSPLAG00000005142.1.
DR   GeneID; 106963199; -.
DR   GeneTree; ENSGT00940000158438; -.
DR   OrthoDB; 22721at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   CDD; cd22265; UDM1_RNF168; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF145; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP ISOFORM X1; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 2.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          151..185
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          176..294
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          361..553
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          30..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          866..904
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1156..1177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1182..1241
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        33..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1288 AA;  144656 MW;  5F5A91DD7E0E8138 CRC64;
     MDTSSKTWLP HQGQFGLVGQ AEVCCGGPGV LTPNQSRRAS FASVRQSSME TPPNTTPQPF
     RQPSFLNRRL KGSIKRAKSQ PKLDRTSSFK QMILPRFRSA DQERTRLMQS FKESHSHESL
     LSPSSAAEAL DLVLDEDAII KPVHSSILGQ EYCFEVTTNS GTKCFACRSA SERDKWIENL
     QRAVKPNKDN SRRVENVLKL WIIEARDLPA KKRYYCELCL DDMLYARTTS KPRTDTVFWG
     EHFEFNNLPT IRSLRLHLYK ETDKKRRKEK STYIGLVSIP ISSITGRQFV EQWYPVIQSS
     VLAKSGGVGS AKVINASLRV KSRYQTMNIL PMELYKEFAE YITNNYRTLC AVLEPLLSVK
     SKEEVAFALV HILQSTGKTK EFLSDMAMCE VDRFMDREHL IFRENTLATK AVEEYLKLIG
     HRYLKEAIGD FIRALYESEE NCEVDPMRVP PSVLADHQAN LRMCCELLLC KIINSLCIFP
     RELKEVFASW RARCAERGRE DLADSLISSS LFLRFMCPAI MSPSLFNLMQ EYPAERTSRT
     LTLIAKVMQN LAIFTKFGPK EEYMYFMNEF LEMEWGSMQQ FLYEISNMDT GGNAGGFEGY
     IDLGRELSML HSLLWEVMGQ LSKDAILKLG PLPRLLNDIS VALRNPQLHM PTNHQPERPK
     DRLFSRPSFN RLMSSDFQSL MMRDLNSSID ISRLPSPTTG VSAVESLSSN LNMRRQAERD
     LRSSSREVFY VTRPPLARSS PAYCTSSSDI TEPDPKVHSV NKSVSMMDLQ DSRMNSISNL
     NSVGDMLASS QASIAGLGHS FGNLGAPLRM GGHLPPGSSG SGLRLSQMGH VGAPTESISQ
     QQQQAAAAMH FPLSFQNPLF HLAAQNSPAQ SQAPPPAAAP PPLLLTPEAE NGHPDYPPAF
     GNSAFSRSED LSALQSQSSL VQPSIVHSHS YSDDFTRQNQ NNDYAWHQLS LQVQESLQQH
     HLMGVTSQTG TGTGTPASLA TPPTTVHPSR QSSIAAQHLK SQRSINMPAT ATPPKVRPQS
     RNLLLNSSDA SFSGSQPKSR PSKQATQQQQ QQQQQQQQQQ QQQQQQQDGQ LSVTDSPAPG
     LPFQTSSAKE NHSPAAAAED STDTPTKSTK KSQQSQLQPP QQHLLKPVAN KQGNSQGMNE
     RTVAWVSNMP HLSADIESLR PDREGQLKEY SKSMDESRLE RVREYEEEIH SLKERLKMSH
     RKLEEYEQRL LSQEQQTSKI LQQYQNRLED SERRLKQQQL EKDSQIKGII SRLMAVEDEL
     RGGAIPDIKP RILTDQSLSQ VYGGLPGS
//