ID A0A3B3V950_9TELE Unreviewed; 51 AA.
AC A0A3B3V950;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Insulin {ECO:0000256|RuleBase:RU000406};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000021414.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000021414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC cell permeability to monosaccharides, amino acids and fatty acids. It
CC accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC synthesis in liver. {ECO:0000256|ARBA:ARBA00002985,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR AlphaFoldDB; A0A3B3V950; -.
DR Ensembl; ENSPLAT00000011037.1; ENSPLAP00000021414.1; ENSPLAG00000005351.1.
DR GeneTree; ENSGT00940000177067; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 2.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR11454:SF9; INSULIN; 1.
DR PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR00277; INSULIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU000406};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW ECO:0000256|RuleBase:RU000406};
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU000406};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT DOMAIN 8..50
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 51 AA; 5675 MW; 9DB1B0C22394E9C0 CRC64;
ALGVAPPQHL CGSHLVDALY LVCGDRGFFY SIVEQCCHRP CSIFDLQNYC N
//
