ID   A0A3B3V993_9TELE        Unreviewed;      1495 AA.
AC   A0A3B3V993;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=ADP ribosylation factor guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSPLAP00000022330.1};
GN   Name=ARFGEF2 {ECO:0000313|Ensembl:ENSPLAP00000022330.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000022330.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000022330.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004556}. Golgi apparatus
CC       {ECO:0000256|ARBA:ARBA00004555}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSPLAT00000008728.1; ENSPLAP00000022330.1; ENSPLAG00000006900.1.
DR   GeneTree; ENSGT00940000158950; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR   InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR   InterPro; IPR046455; Sec7/BIG1-like_C.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF124; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF20252; BIG2_C; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF09324; Sec7-like_HDS; 1.
DR   Pfam; PF12783; Sec7-like_HUS; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          352..541
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          303..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1213..1251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1223..1238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1495 AA;  170000 MW;  0B2408A16F9C15D2 CRC64;
     MLNVIFTRME NQAVSTTCYS SPRSYCQIHH FRSEPTNQSQ EGLSTVSHAH VNYSANCRVS
     HAVVLSQDAD ALHGPNNAAR FSHILQKDAF LVFRSLCKLS MKPLADGPPD PKSHELRSKI
     VSLQLLLSVL QGAGPVFRTH EMFVNAIKQY LCVALSKNGV SSVPEVFELS LAIFLTLLSH
     FKVHLKMQIE VFFREIFLTI LETTTSSFEH KWMVIQTLTR ICADAQCVVD IYVNYDCDLN
     AANIFERLVN DLSKIAQGRS GQELGMTPLQ ELSLRKKGLE CLVSILKCMV EWSKDMYVNP
     NLQANLGQEH PPDSEGGELK LPEQTAGRRD SVSSLDSNYS SITMSQADHP EQYEVIKQQK
     DIIEHGIELF NKKPKRGIQY LQDQGMLSST VEEIAQFLHQ EDRLDTTQVG EFLGENTKFN
     KEVMYCYVDQ LDFCGWDFVS ALRTFLEGFR LPGEAQKIDR LMEKFAARYL ECNQGQTMFA
     SADTAYVLAY SIIMLTTDLH SPQVKNKMTK EQYIKMNRGI NDSKDLPEDY LSSIYDEIAG
     KKIAMKESKE FSITPKSTKQ SVASEKQRRL LYNMEMEQMA KTAKALMEAV SHAQAPFFSA
     KHLEHVRPMF KLAWTPLLAA FSVGLQDCDD PEVASLCLEG IRCAVRIASI FSMQLERDAY
     VQALARFTLL TASSSITEMK QKNIDTIKTL ITVAHTDGNY LGNSWHEILR CISQLELAQL
     IGTGVKTRYI SGVVRDREGS IRGLPPGTEE FMPLGLGNLV GSQDKRQMAH IQESVGETSS
     QSVVVAVDRI FTGSTRLDGN AIVDFVRWLC AVSMDELASA HQPRMFSLQK IVEISYYNMN
     RIRLQWSRIW QVIGDHFNKV GCNPNEDVAI FAVDSLRQLS MKFLEKGELA NFRFQKDFLR
     PFEHIMKKNR SPTIRDMVIR CVAQMVNSQA ANIRSGWKNI FSVFHQAASD HDETIVELAF
     QTTGHIVMKT FQEHFAAAID SFQDAVKCLS EFVCNAAFPD TSMEAIRLIR HCAKYISERP
     QALREYTSDD MNVAPGDRVW VRGWFPILFE LSCIINRCKL DVRTRGLTVM FEIMKSYGHS
     FEKHWWHDLF RIVFRIFDNM KLPEQQTEKI EWMTTTCNHA LYAVCDVFTQ FYEPLSEILL
     QDIFTQLQWC VRQDNEQLAR SGTNCLENLV ILNGEKFSPE VWDVTCSCML EIFQNTSPNA
     LLTWRPAGQD EEAAEGKHFE TDFDSQSQSS FDRALSERGH SQMSSDDTWK GKSSAISDQR
     LFAGLLIKCV VQLELIQTVD NIVFYPATSK KEDADNMAAA QQSEAAGEEP ASDQGMYRHM
     TSAHLFKLLD CLLESHNFAK EFNSNNEQRT ALWRAGFKGK SKPNLLKQET SSLACSLRIL
     FRMYSDPKLQ DSWPDIQTRL LLVCTEALSY FISLTSESHR EAWNSLLMLL LTRTLRLPDD
     KFKPHASCYY PHLCEMMQFD LIPELRAVLR RFFLRIGSVF QIAAPDGAAA RTPVS
//