ID A0A3B3VCQ5_9TELE Unreviewed; 763 AA.
AC A0A3B3VCQ5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSPLAP00000022747.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000022747.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000022747.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B3VCQ5; -.
DR STRING; 48699.ENSPLAP00000022747; -.
DR Ensembl; ENSPLAT00000007661.1; ENSPLAP00000022747.1; ENSPLAG00000007561.1.
DR GeneTree; ENSGT01100000263565; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF504; EXTRACELLULAR CALCIUM-SENSING RECEPTOR ISOFORM X2-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 478..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..748
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 763 AA; 84576 MW; 8E15C76AD7320C71 CRC64;
MRLAVEEINE STELLPNHTL GYKIFDSCAY PLTGQRAALA VLNGLSEADS PMCSGSSPML
TVIGESGSAQ SIVVSRLLRP FRIPMVTASP FLCSHLSILI IPNDDYQVKA IAQLLLHFNW
TWVGLIRGDH EYGRFAVQGL LRELQGSSVC VAYQEMIPLL YNTQRALEIM QVHFQSSTYL
VIMQNNCKQN ITGIQWVASE AWVTASVFTG REFYPYLGGT IGFGIRKGHI AQLGDYLQTV
SPQRYPDNIL VGELWEALYG CSPFPSSANR FPVCSGQEVL LKQHSAYMNT SSPRVAYNVY
KAVYAVAHSL HNLLLCQSGN GPFENDSCAQ SNNILPWQLQ YYLQEVKFNM AGEEVNFDQK
GDSVPYYDII NWQRGTTGSI EFVNVGLFDG TKPGGEELVI QEERIMWTGH QMSVCSPSCP
PGSRKAVRRG EPVCCFDCVP CDSGKISNQT NSVECIFCPE DFWSNQDRTS CIPKKVEFLA
YDALGIPLTV ISVVGASLTV GVFVVFFHHR RTAVVRVNNS ELSFFILFAL TLCFLCCLIF
IGEPTVWSCM LRHTAFSITF SLCISCILGK TLVVLAAFTA TRPGDNIMKW LGPKQQRAII
FSCTLVQVVI CAAWLIDAPP YPSRNTKYER SKIILECSVG SSLAFWCVLG YIGLQACLCF
VLAFLARKLP GNFNEAKYIT FSMLIFSAVW LAFVPAYVSA PGNYAGAVES FAILASSFGL
LFCLFAPKCY IILLKPEKNT KQHLMAMIKS IKLLIPSADE ALK
//
