ID   A0A3B3VFE0_9TELE        Unreviewed;       417 AA.
AC   A0A3B3VFE0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=THUMP domain containing 2 {ECO:0000313|Ensembl:ENSPLAP00000024470.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000024470.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000024470.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
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DR   AlphaFoldDB; A0A3B3VFE0; -.
DR   STRING; 48699.ENSPLAP00000024470; -.
DR   Ensembl; ENSPLAT00000003310.1; ENSPLAP00000024470.1; ENSPLAG00000010700.1.
DR   GeneTree; ENSGT00530000063557; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          115..208
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|SMART:SM00981"
SQ   SEQUENCE   417 AA;  46580 MW;  2EF07DCB60AF28EA CRC64;
     MPEVRSEDSV VRYYCTAGNG MEPFLVDEVK RKLAAQDVDH IPGKVLFSSS ETIHRVCDLK
     AAERLFLLLK QDSPVRLSTH TSPGTTKAAS VLQSRLLGDR TQMTWEKTLL WEAWRMVRMH
     RFVRSQLQSD DFWVMRNKPY LLFFSPVSFR INCKCSGKLH RCISAQEVSR VMGMGLSRLL
     GWKADLKNPK LEINVYLNDD YCLLGIPLTR LLLPLANRSY LKTPGLRSTV AWAMASLALI
     EAACFLGVDI DDGQLQKADE NVLFAELQSR VHLLKASSTA LPLPSASVDA VVCDLPFGRK
     FSTRINMAEN LPVILSEMER VLRVGGTLVV LLSPQLSCLL KKLLLQTNCG PKRNEEAESQ
     TGMKSCLVSS SEQHNLQVTS SSSQEASTFS SLRHQATLRV SLGVIDGLIH KYIKTLD
//