ID   A0A3B3VFM5_9TELE        Unreviewed;      1441 AA.
AC   A0A3B3VFM5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSPLAP00000023619.1};
GN   Name=ARHGEF10 {ECO:0000313|Ensembl:ENSPLAP00000023619.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000023619.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000023619.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_014894922.1; XM_015039436.1.
DR   STRING; 48699.ENSPLAP00000023619; -.
DR   Ensembl; ENSPLAT00000005469.1; ENSPLAP00000023619.1; ENSPLAG00000009184.1.
DR   GeneID; 106951745; -.
DR   KEGG; plai:106951745; -.
DR   CTD; 9639; -.
DR   GeneTree; ENSGT00940000153798; -.
DR   OrthoDB; 2916834at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          492..679
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1300..1339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1357..1376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          379..430
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..34
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1300..1334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1441 AA;  158775 MW;  ED18E32A0FDD2A71 CRC64;
     MDVDEFPPPP PEMLADNVPF DDEDEGEPFD FDSGDDIPEA PPAPPSFPSE DPSQANSVTG
     HPDGSYSNLD PPAQFSNLAP TSEDAAVATS KPSSAGRETT ETEETSVAEG TNDREEDLPP
     LPSPPPPVGY GIQTDPRSTD TEGESASLND PHPPQGLPRT SSQSKVNPYS VIDITPIQLQ
     QEQQHGPSSS TSSPRESKVR EEEGQDIHTS SSSITSGYSV PVPCGYATPS GVPLITPAYT
     TPVIIRHLSV DEDVTVVGTS NTSADSVFSE ENPAIAEEDA LAKWASDPAN TAWMENPDEV
     IYDDVPRENS DSNTDPDEMI YDDVELGEEG GCSSSLDNGW SSSEFESYDE ASDGEDRPEN
     GLPHAFMRGK PSQRKMHLSQ DLTRLKEHYE KKMKELMAST VGAVELQQLK QKHEQKMQKL
     VKAAKEGTKD GLEKTKAAVK RGRSFIKTKS FCQERKLACF EDESEVFIEV DCFNVEPVLP
     PTPQGLSQQQ LVRRCILGSI LDSEKNYLDA LKRILEQYEK PLSQIEPRLL SDRKLKIIFY
     RVREILQCHF LFQIALASRV SEWDSLEMIG DVFVASFSKS MVLDAYSEYV NNFSTAMAVV
     RKTCASKPSF LEFLKHRQES SSDRMTLYGL MMKPIQRFPQ FILLLQDMLK NTPVGHADRL
     PLQMALTELE TLAEKLNEKK READQRCEIR HIAKAMNERY LNKLLSNGSR YLIRSDDMVE
     TVYNERGEII KTKERRLFLL NDVLMCATPN IRCQDGSGSG SGNAPFDQKF LLKWSVPLNF
     VEVLEFGSSE EMVDNSRYPA PHSGEKVVIN AKPNKLYMGP GQLYQDLQNL IHDLGLVNQI
     AGMIGSLKGN YQNVNSTVAQ DWVSGLQRLI LKKEEEIRAA DRCRIQLQLP GKNDKAGKPT
     YFSAVFNTLS PAIKQSWISN LQMAKLALEE DNLQGWFFAD DDGNHIKKQK HPLLLRQMPV
     VMSKLQEFKV ECAVHNPEPY INTESTADSP VVGHGCVWVA SCTNQMGQIA IVAMQNSCPK
     VTECFNVESR ILCMAYVPTE QLKEDGEKLP DSNYAPPAKA SDTPTVCLGM EEGSIIVYKS
     TQRSKKIRLQ HFFTPDKSTV TSLVYKKPCL YAGLVSGAVA IYSRSQDGSW SCEKPKLLKL
     GVLPVKAVLA VEDHLWASSG GQVFIIGTHT HCVERQLEAH QEEGMVVSHM VVAGVGIWIA
     FSSGSTVRLF HTETLEHLQD INIATTVNNI LPGNQRVSVS SLLVCHGLLL AGTNLGVTVA
     LSVPRLQGIP KVTGRGMVSL HAHNGPVKFL TMATAVRNWS SSLPSSTPSS SLQQIESVDA
     DSAQPVSDTA SSPPQGRGVW LGEAGCTTMA LQDSLSSSSC GSLAPSQASL EHGPEDGALY
     DLLHDPAHHQ RGRRSSKMDV SSLLVVSGGL GHRRVNKKTK QSRHEDNTST IMIWQIPLLN
     M
//