ID A0A3B3VFU0_9TELE Unreviewed; 261 AA.
AC A0A3B3VFU0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000023878.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000023878.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
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DR RefSeq; XP_014874780.1; XM_015019294.1.
DR RefSeq; XP_014874781.1; XM_015019295.1.
DR RefSeq; XP_014874782.1; XM_015019296.1.
DR RefSeq; XP_014874783.1; XM_015019297.1.
DR RefSeq; XP_014874784.1; XM_015019298.1.
DR RefSeq; XP_014874785.1; XM_015019299.1.
DR RefSeq; XP_014881722.1; XM_015026236.1.
DR RefSeq; XP_014881723.1; XM_015026237.1.
DR RefSeq; XP_014881724.1; XM_015026238.1.
DR RefSeq; XP_014881725.1; XM_015026239.1.
DR RefSeq; XP_014881727.1; XM_015026241.1.
DR RefSeq; XP_014881728.1; XM_015026242.1.
DR STRING; 48699.ENSPLAP00000023878; -.
DR Ensembl; ENSPLAT00000004807.1; ENSPLAP00000023878.1; ENSPLAG00000009617.1.
DR Ensembl; ENSPLAT00000029972.1; ENSPLAP00000027983.1; ENSPLAG00000017029.1.
DR GeneID; 106937667; -.
DR GeneID; 106942890; -.
DR KEGG; plai:106937667; -.
DR KEGG; plai:106942890; -.
DR GeneTree; ENSGT00390000009853; -.
DR OrthoDB; 1472480at2759; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 19..253
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 261 AA; 28673 MW; C07DF351F7B6320F CRC64;
MHVLLLKEPR DEESAPDPYM KELESHGHKA TLIPVLSFKF VSLNTFSDKL FQPEKHGGLI
FTSPRAVEAV KMCLDMGGRR EEWNKSIKDK WNSKSIYVVG KATAALVQSL GLKPLGEDTG
TADVLSRLII EREDTDIPPL FFPCGSIKRE VLPTALRENG VPLETLTVYQ TAEHPDLEKN
LKNYFTEQGT PACIAFFSPS GVKFCLEAVR RLSGEQLNEI KFAAIGPTTR DAMAAEGLCV
SCTAEKPTAE HLAAAIATAL Q
//
