ID A0A3B3VHJ1_9TELE Unreviewed; 725 AA.
AC A0A3B3VHJ1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSPLAP00000024274.1};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSPLAP00000024274.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000024274.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000024274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3VHJ1; -.
DR Ensembl; ENSPLAT00000003801.1; ENSPLAP00000024274.1; ENSPLAG00000010443.1.
DR GeneTree; ENSGT00940000158723; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 135..194
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 210..390
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 507..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 690..717
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 725 AA; 81599 MW; 6F2F360C6B25871F CRC64;
MNPEEQTVTW LISLGVLSSP KKNIADPEEF LKTSLKDGVV LCKLTERLIP GFTPKYSQDP
RTDADCISNI KEFLRGCSSL KVEGFEPEWL YTGENFGKVL NTLLAFNFAT QGNSSHLFLC
CGSLFKQEMS ENGGGGQVMV KARFNFKQNN EDELSFSKGE VIIVTRQEDG GWWEGTLNGK
TGWFPSNYVR EIKPCEKPLS PKGIPLTKNY FSVVVQDILD HEREFVKELQ TVLTCYLRPL
QASDKLSSGD SATLCGNLEE ILTFQQGLCS ALEDCTKVAE GQQRVAGCYL NLMSQIKSLY
LNYCSSHPSA VCILTDHSDE LGKFIESQGA SPSGILTLTT SLSKPFIRLD KYPTLLQELE
RHVEEAHPDY GDIIKATAAF KSLVSQCQDL RKRKNLELQI LSEPVRGWEG DSMKSLGQVA
YTSQVHVRNG ASEEKEERYL MLFPNVLLML SASPRMSGFI YQVRHNVLCM YFYTYIEKRG
MVDRFSVFCS SPQELQEWLE HLQPYTKSGS PTVGTPTHLP HLGGPSAVSR GPLEPPKTSK
PWTLSCLRPA PPLKPSAALG YKEFVVVLLQ DSSKSPRPIK KFLPGNRKKD RKPSDDEFQI
RKSTAALEED AQILRVIEAY CTGASLHQTT TGVSVRKECV PQVLLPEEEK IIVEEIKSNG
QTVTEEKSLV DAVYALKDEV HELKKENKWM KQFLEEEQKS RKELERLVRK LSKQKNDCGW
EDSSH
//
