ID A0A3B3VJA6_9TELE Unreviewed; 263 AA.
AC A0A3B3VJA6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Apolipoprotein A-I-like {ECO:0000313|Ensembl:ENSPLAP00000024869.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000024869.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000024869.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC tissues to the liver for excretion by promoting cholesterol efflux from
CC tissues and by acting as a cofactor for the lecithin cholesterol
CC acyltransferase (LCAT). {ECO:0000256|ARBA:ARBA00037506}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR RefSeq; XP_014916342.1; XM_015060856.1.
DR AlphaFoldDB; A0A3B3VJA6; -.
DR STRING; 48699.ENSPLAP00000024869; -.
DR Ensembl; ENSPLAT00000002306.1; ENSPLAP00000024869.1; ENSPLAG00000011411.1.
DR GeneID; 106965007; -.
DR KEGG; plai:106965007; -.
DR CTD; 100101640; -.
DR GeneTree; ENSGT00950000182929; -.
DR OrthoDB; 4256926at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 1.20.5.20; -; 1.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF11; APOLIPOPROTEIN A-I; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..263
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017231832"
SQ SEQUENCE 263 AA; 29432 MW; 229B84062FCB97D2 CRC64;
MKFVALALAV LLAVGSQAAS LQADAPSQLA HIRAAADVYM TQAKESAIKA LDQLDDTPYQ
ELKASLAQRL EDIHNNIKQM QAQVSPMTDT VVSSISDATA ELRASIAADI EALRAELEPQ
RAKLREVIEK HLEEYRTHLE PYVREYQAKQ NAEMEALRAK MEPVMEELRQ KVATNLDETR
AALMPIVESV RTKLVERLEA LKAMATPYVE EYKEQLRQAY SQAQGVNAEQ ITSLREKLTP
LGEEVKEKLQ AMAAIIRDTF SKN
//
