ID A0A3B3VJV1_9TELE Unreviewed; 1010 AA.
AC A0A3B3VJV1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Integrin alpha-7-like {ECO:0000313|Ensembl:ENSPLAP00000025296.1};
GN Name=ITGA7 {ECO:0000313|Ensembl:ENSPLAP00000025296.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000025296.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000025296.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3B3VJV1; -.
DR STRING; 48699.ENSPLAP00000025296; -.
DR Ensembl; ENSPLAT00000001202.1; ENSPLAP00000025296.1; ENSPLAG00000012256.1.
DR GeneTree; ENSGT00940000159891; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 949..973
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 16..82
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 289..350
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 351..407
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 411..470
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 485..590
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 592..753
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 759..925
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1010 AA; 112347 MW; D275D8D9B3EE09E0 CRC64;
NLPSALLHHV YCFNLDTTHT LHKLGDRGTF FGFSVALHQQ LNPKPQSWIL VGAPQAAGRG
PLTGSRPGAL FRCPITPEEY DCERVNIDGE VSLDRESKDN QWLGVSVKSQ GIGGKVVTCA
HLYELRQRVK QPSETRDPIG RCYVLSDDLT RRDDLDGGEW KFCEGRPQGH EQFGFCQQGL
SVSFTPDRNF ILFGAPGTYN WKGELRVELL NQTVLELGFY DDGPYEVADY NELNALLIPL
PYHSYLGFSV DSAKGIMNLK ELTFVAGAPR ANHTGAVVLL RKDNVHRLVP QHIFWGEELA
SSFGYSVATT DLNKDGWTDV IVGAPNFFDR KAEIGGAVYV YLNPLGHWDD QARPIRLNGT
YDSMFGMTVS SIGDLDQDGY GDIAVGAPFD GDGKVFIYRG SDAGIETKPA QVLDGHDFDV
TRFGYSISGG LDIDDNHYPD VVVGSLNDSV VLFRSCPVIH VVREVSIDPQ NIDLDQKNCK
GRDGFEADAE RRKLGLPHRV SFLGHSSLEP EYTQTEEVEL HRQRETHCVL LPVLQENILD
KLRPISLVIT HSIKPVPPRR NSSKRPQKLP PVLNISPSKT LNSEVNFLRE GCGSDKICQS
NLKLSYQFGT THLNSDFFTP LPRDNDGVQV FSLSDQRLVV LEVTVTNMPS DPLNPEEDGD
DAHASQLFIT LPDTLPYVFD VPQLQMICQA NQNGSQVECD LGNPVKRNAK LKFTINLSTS
NITTETTELT ADLQLATISE QLNLDPVTAF AKVVIELPLS VNGLARPHQL FFSGTVKGES
AMTSLEDIGN TVDLEFVLSN PGKALQKLGS AFLNIMWPFE LPNGKWLLYP ASLRFEGQPD
TRCSPTEAVN PLNLQSSSAA NQVVGGTGVR VTQLFPNLHL HPKLHDCLLG SARCVLFQCP
LHSFTGQAVL KIHARLWKSS FIENTLRGKM YVIPVMIYPE LDLAEQYMIP WWIILIAILA
GILLLTLLVC ILWKCGFFKR SERRPHYETE YYRAHLGVQP SEAEKQALEL
//
