ID A0A3B3VLA6_9TELE Unreviewed; 1049 AA.
AC A0A3B3VLA6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Rap guanine nucleotide exchange factor 1-like {ECO:0000313|Ensembl:ENSPLAP00000025793.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000025793.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000025793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3VLA6; -.
DR Ensembl; ENSPLAT00000017237.1; ENSPLAP00000025793.1; ENSPLAG00000013171.1.
DR GeneTree; ENSGT00940000156235; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 660..782
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 812..1036
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 21..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 118448 MW; 0DD277EE31DFB802 CRC64;
MSRKIESKQD SQRSHLSTFT MILKDKFHSP KIKRTPSKKA KQLQPEPSAK STEKPANKKV
SRLEEHEKEV VSALKYFKTI VDKMVVEKKV LEMLPGSASK VLEAILPLVQ IEARIQHSSA
LSSCHSRVYQ SLGNLIRWAD QVMLDGIDLD DKESVIAVTS VIKAVLDGVK ELVKLTIEKQ
EQPSPTTPNK PAPPVTTAES NVSVEVPLID TEQEVSSRTA PVTSPAKVAP ELQDEDVAPP
KPPLPEAKVA ELSPPPALPP KKRQSAPSPT PVAVVAPMSR GSSLPCSDHR QEYEQEFFQR
RFSGGSHSYG GDSPRLSPCS SMGKLSKSDE QLSSMDQDSG QCSRNTSCET LDNTESYDPD
YDFLHQDLSA GDNLPAVQVG GCLSPLPESH SESSSPVPGQ HLAHPPLSAP PSQQQEYWTP
QPNQSNPLQS CRTSAPPALP LKKRRSTQTS SFSDGGSRVL YERYPSQYDN LSEEELHPTP
PFPLFTPISP MPQTNGGVFV SQFMASENAD VPANPPPLPE KKNRHILQYM QFMEDYSEPQ
PSVFYQMPQS ERIYEQHNKL FQEVYGFNDS FSSTDSVHEP LQPPALPPKQ RQLETIAADD
VLQDPAPQMP SSNSKEALDK ERRQKTAETA GSVEEDVDEL SLIDHKEIMS RITLKQENDD
GPDVRAGSGD ILLVHATETE RKDLVLYCEA FLTTYRTFIT PEDLIKKLHY RYTTFCHSPD
TFKKRVSKNT FFVLVRVVDE LCLVELTEDI LKQLMDLVFT LVCNGELSLA RVLRKNILDK
VEQKKLLRYT NSLKPLAARG VSARPGTLHD FRSHEIADQL TLLDAELFYK IEIPEVLLWA
KEQNEEKSPN LTQFTEHFNN MSYWVRSLII QQEKAQDREK LLLKFIKIMK HLRKLNNFNS
YLAILSALDS APIRRLEWQK QTSEGLEEYC TLIDSSSSFR AYRAALAEVE PPCIPYLGLI
LQDLTFVHLG NPDLIDGKVN FSKRWQQFNI LDSMRRFQQV HYELKRNEEI ISFFNDFSDH
LAEEALWELS LKIKPRNVNR AKTDRGEKT
//