ID   A0A3B3VLC5_9TELE        Unreviewed;       684 AA.
AC   A0A3B3VLC5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 {ECO:0000313|Ensembl:ENSPLAP00000025791.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000025791.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000025791.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3VLC5; -.
DR   Ensembl; ENSPLAT00000017219.1; ENSPLAP00000025791.1; ENSPLAG00000013138.1.
DR   GeneTree; ENSGT00940000167370; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd17211; RA_RGL2; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF350; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 ISOFORM X1; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          44..169
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          203..462
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          567..653
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          173..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..562
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   684 AA;  76912 MW;  6B4537DB0541C340 CRC64;
     MKTTWYCPLD LSTVVEEEDE GVIYTVVVKQ QHASPNSPAS TVSRSQCVKA GTEEKLVLHL
     LHSFSLGDSS FISIFLSTYR SFTSTERVLD ILTDRLENPP GDSERSQTRQ SFNKAVCTVF
     STWLSEYPED FRNLGDPSRL LRLAPLLPQD SSSAVDLRAR LLRTAEELSE RALLPDKHRD
     QSSSSSSPPD PSKFEPTSVL GFPAAVIAEQ LTKIETELFV RLVPYHCLGS LWSQRDKKGR
     EGVCWSVRAT IRQFNKLANA VLASCLWPTK LRSQQRARLL EKWISVAEEC RARKNFSSLY
     AVVSALQSNP IHRLRRTWQE TDREALRRYE ELAEIFSDKD NYSQSRELLK EEGTSKFANL
     DNRINNRHHS RSNAQGTVPY LGIFLTDLTM LDTAVKDRLD NGYINFDKRR REFEVLAQIR
     LLQSSCKNCV FDSDEAFSQW YHSVPTLTEE QSYRLSNEIE APTEPSPRSL MPTVIITQCS
     DLSSSRTSLA GDGESLFDFH SPVNNFLSKL TKHMRSPSVS CLDVDTSPPT NESTPVALTP
     TTPTKTHRRS ASCGNNLPSN VPGSGPDMRI IRIRMDLQDG NLYRSILVTS NDKTPSVISS
     ALEKHNQDPT QASRYELIQL LPEGKELVIP ATGNVFYAMT SSSVDFLLRR KGGNTPVGSP
     ITTETSATFP RIKAKGRRLV RTLF
//