ID A0A3B3VLY2_9TELE Unreviewed; 136 AA.
AC A0A3B3VLY2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Prefoldin subunit 4 {ECO:0000256|PIRNR:PIRNR016477};
GN Name=PFDN4 {ECO:0000313|Ensembl:ENSPLAP00000025849.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000025849.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000025849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC transfers target proteins to it. Binds to nascent polypeptide chain and
CC promotes folding in an environment in which there are many competing
CC pathways for nonnative proteins. {ECO:0000256|PIRNR:PIRNR016477}.
CC -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC subunits. {ECO:0000256|PIRNR:PIRNR016477}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000256|ARBA:ARBA00008045, ECO:0000256|PIRNR:PIRNR016477}.
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DR RefSeq; XP_014912903.1; XM_015057417.1.
DR AlphaFoldDB; A0A3B3VLY2; -.
DR STRING; 48699.ENSPLAP00000025849; -.
DR Ensembl; ENSPLAT00000017327.1; ENSPLAP00000025849.1; ENSPLAG00000013167.1.
DR GeneID; 106962798; -.
DR KEGG; plai:106962798; -.
DR CTD; 5203; -.
DR GeneTree; ENSGT00390000006696; -.
DR OrthoDB; 5476468at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR002777; PFD_beta-like.
DR InterPro; IPR016661; PFDN4.
DR InterPro; IPR009053; Prefoldin.
DR PANTHER; PTHR21100; PREFOLDIN SUBUNIT 4; 1.
DR PANTHER; PTHR21100:SF9; PREFOLDIN SUBUNIT 4; 1.
DR Pfam; PF01920; Prefoldin_2; 1.
DR PIRSF; PIRSF016477; Prefoldin_subunit_4; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR016477};
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT COILED 35..120
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 136 AA; 15219 MW; 27F4375F13E39B56 CRC64;
MAAATMKGPV AVEDVVVTFE DQQKINKFAR NTSRMGELKN EIESKKKTLQ NLQDASDELM
MLDDDSLLVP YQIGGVFIGH SQEETQEMLE AAKEALEQEV KGLEERVTEI QQVLGDLKVQ
LYAKFGNNIN LEADES
//
