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Database: UniProt
Entry: A0A3B3VM33_9TELE
LinkDB: A0A3B3VM33_9TELE
Original site: A0A3B3VM33_9TELE 
ID   A0A3B3VM33_9TELE        Unreviewed;      2212 AA.
AC   A0A3B3VM33;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Thyroglobulin {ECO:0000256|ARBA:ARBA00017326};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000025899.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000025899.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   Ensembl; ENSPLAT00000028784.1; ENSPLAP00000025899.1; ENSPLAG00000016323.1.
DR   GeneTree; ENSGT00940000168460; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00191; TY; 5.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 6.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR   PANTHER; PTHR14093:SF19; THYROGLOBULIN; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 5.
DR   SMART; SM01411; Ephrin_rec_like; 1.
DR   SMART; SM00211; TY; 7.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 6.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 3.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 6.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00500}; Hormone {ECO:0000256|ARBA:ARBA00022702};
KW   Iodination {ECO:0000256|ARBA:ARBA00022653};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW   Thyroid hormone {ECO:0000256|ARBA:ARBA00022920};
KW   Thyroid hormones biosynthesis {ECO:0000256|ARBA:ARBA00022534}.
FT   DOMAIN          37..87
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          88..186
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          227..287
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          482..538
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          539..604
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          795..846
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   REGION          302..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1992..2018
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        67..87
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT   DISULFID        267..287
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT   DISULFID        518..538
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ   SEQUENCE   2212 AA;  242273 MW;  76F3B77B03702B8F CRC64;
     EALSRCEILR SVAVGTKQEE VPHCLEDGSF SCPVPGPTPC QLQSLLQCAP SGLFEPVQCD
     SRGRCWCVDQ DGMELYGTRQ ASIPRRCPSS CEVRSRRLLH SSASSPPQCA ADGSFLPVQC
     KFINTTDRTE LDLVKCSALC SSSPEAFETF RNFRKFFPLV SSYCFCSDSR GRELQGTGVE
     LLMSEVYDSA FSGPRSAHSF AQTNIYRVLQ RRMLGVRLAL SGHFRCPSPC EEERRAALES
     SSVFVPSCEA DGRFSAKQCQ QGALCWCVDP TGRELTGTRR PGDGLVCGED ELHHLVGCCS
     RSKRRTDSPL TPPPGSGPAD CPAQRRLALS QLFSGLVRPP QASSGSATLC LSLLRPLRVL
     GYSDPTSFLS RLVEVLQGLF PSVGGALEAL TRSPAQRLQE NLFGGKFLQN VAAFNYTGVL
     GPRGAVGVDQ LSAQSLQENR DLVRAVSRAL EDPAFLSALR QTLMVLSGAP SGSLQQVLAG
     VLRSCSEEED DSSSLFVPRC SLSGGYQPVQ CRDAECWCVN LQGQEAPGSR TAGWPPRCPT
     SCEMARANAM KVKSNMAAGA EIHIPACSED GDFLPLQCVG DRCFCVDAEG RKMAAGPTGG
     AVTCEFLLHQ NVSDISFTFD LSGRCSKALA EVTAFRQEVD SLVFLSNSTH LPVGYGFLLA
     KGLSLSQSEE ELQLSQSEEL KVSERLLSRS RSALRLAASS SELQRHKLQE FNLKYQMYLQ
     ITLQKCWCVD EEGEFIPGSL RRSLRLPRCR SRCQRAEAHS LLSDWMKASD ITTASPYHPQ
     CEQGGSVNSV LPSGPSWCEL QRLRCRPDGS FDPLQCDVTS CWCVSEDGQE MAGTRSLRQT
     GRTPSCDRPL CPAPNITHGA LVCHPAADGR QSCDLVCHHG YQNSLPVSSF LCSIKSRQWD
     EGDKPLSGAC QSESVRFYFV LFIFLLPSGR SVALCGDSAV GLWCDAGDSV RLTLRWTADL
     SDLTTSDLPH LHHMGEYSLN RDSNFMRRFV PAGLRPAQAH GSIVSFPVVC PAGSFYQQGV
     CLLCPQGTYQ ELEGRDFCTR CPRGSSPAGA SAANQCETDC ERRGLRCSQS GDFLLAQPNF
     LSGGWRCVSN EGVELEWTSR EERLTDEECS GEDQFGPGSG LGCERPVFVS ACAVEPSCHH
     VALFDRRTRC DLYSSLNAVC SASQQVSRLR VKGQPFRARI LLQLCVFLQA TGFLGNPRAE
     RFHQLRCSLR VRGGASDLFV LRKNGAELQH QSFVRMRMRK AVSGVFRTQV FSSRNTSLSD
     VRRFCQDGCS RDACCHGFIL NQNVLDGGSL LCGWLRAPSV LMCEDEDWDV IGQGPANRIC
     GAGLSYSKQQ RSFEFDFGGE KFTISKKATQ LGLTSPVQTQ TECSGSVQLT ALCLATAETG
     RTTRPPSSTL VLSAATVQLR FQSLSSAEVL VDPQRKQPVL SFWLSKNDYS SQNALLWCLT
     RMQLSVLTDS DRFFRCALYP DTRVCGGYDQ PIRRSCRPLL DRATNNTYSK KVDLSGPVQS
     FYERVPFQKM VSYSVRNRPS SMFSSRAVSV SRFRECERRC DEDPCCRGFG FVHETKSRGL
     LCLPLISLGV LTCSEDDAST WRTQDCSPPE AETSPEPFGW YQKPGTRLTQ TRYSTVSVCV
     RPESVSVFMD DWRLLSESSL LIDASLSTYD VIHVSRDIDT DRERTRDWCL HADEPITEQN
     RAWQLTDPNV FLERSPQAAS ISVPGHGTLQ GVAMETAVGS DRRTVIRFLG VPYARPPIGV
     LRFEAAQLAD WTGTWDATNL NHQNLGVRTI SDPPVPSSED CLYLNIFTPA VQVIPVLVYF
     FNPPANQNQN LLDGSALAAL GNIVVVTASY RTAALGFLTA GGLHGNYGLS DQEAALRWVH
     AHISLVGGDS GSVTVGAERR GADISSLTLL SSSPPFHRMI LMGGSVFSPS LVQTASAGRR
     QAVDLARELG CVTSDLSDDG PMVACLRSTP VHKLNAAQTK VRVLRSRQFC PAGGQRSVPG
     LGSGPQVRVR VLPQSGPDAG HIRTRRPDQQ STQDKGQRSL KTAFYEALSR SLGGASGNAL
     LKDAAAWFYS LDHDPSAAGY NLFSRALNNA TRDLFIICPT VQMALHWAAS GTNIFQYHQP
     ASTDVLVPLD VQFLFGIPLQ PMNSQRFTSS DRRLSLAVMT YASSFIRTGN PNPSHVWAES
     VLPRWQPVTA EAPPTYLELS PALQHQQGLR QNACSFWREL GTRLTSKTGR FC
//
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