ID A0A3B3VPC7_9TELE Unreviewed; 638 AA.
AC A0A3B3VPC7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000026684.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000026684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR AlphaFoldDB; A0A3B3VPC7; -.
DR Ensembl; ENSPLAT00000019018.1; ENSPLAP00000026684.1; ENSPLAG00000014699.1.
DR GeneTree; ENSGT00940000165253; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF83; ACETYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|RuleBase:RU361147};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU361147}.
FT DOMAIN 54..109
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 111..500
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 638 AA; 71276 MW; BD4F12B90113BA91 CRC64;
MWLPCRCTTK YVAASIRRGV SASSLHALRR GRSSWNSAAF MPESAGFEGV SGRDALHDYS
VSHSENFWAA VARQRLNWIR PFEAVQDCDL SQGRIKWFEG GKLNVSVNCL DRHVHTCPER
VALIWERDER GSEVRYTYRE LLEMTCRLGN LLRRHGVKKG DCVTIYMPTC PLAVASMLAC
ARIGAAHNVV FAGFSSEALA ERIRDAQSST VITVNQGVRG GKITELKRTV DAAVQSCPTV
RQVFVAMRTE KRVEVTDRDF ALEEEMLKED VVCEPAAMDS EDVLFLLYTS GSTGKPKGLV
HTQAGYLLYA ALTHRYVFGY HDGDVFGCVA DIGWITGHSY TVYGPLANGG TTVLFESTPV
YPDPGRYWDM VERLRINQFY GAPTAIRLLI RYGDQWVKKY DRSSLTTLGS VGEPINTEAW
EWYNRVVGEG RCPVVDTWWQ TETGGICIAP KPSEPDAEIV PGMAMRPFFG IKPALMDTEG
KLLTSNNASG ALCMAQPWPG MARTIHNNHQ RFLETYFQPY PGYFFTGDGA YRSQEGYYQI
TGRLDDVINV SGHRIGTAEI EDVVVIRSDE AHLSDFILII SVTQFAKRLP KTRSGKIMRR
VLRKVVDCDL DSLGDLSTLD DPAAVQEIIE GHEKLLSK
//
