ID A0A3B3VPF1_9TELE Unreviewed; 1724 AA.
AC A0A3B3VPF1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Complement C3-like {ECO:0000313|Ensembl:ENSPLAP00000026709.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000026709.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000026709.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR STRING; 48699.ENSPLAP00000026709; -.
DR Ensembl; ENSPLAT00000019002.1; ENSPLAP00000026709.1; ENSPLAG00000014776.1.
DR GeneTree; ENSGT00940000154063; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF167; COMPLEMENT COMPONENT C3B, TANDEM DUPLICATE 1-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1724
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017415053"
FT DOMAIN 685..720
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1576..1722
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 731..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..749
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1724 AA; 193433 MW; 276C8FF21B77E3F1 CRC64;
MFPWRLQNIL FLLLFCNSDG QIFGSNRRMF TLVAPDILRT DTEENIYLQA DGLPTPLIAS
IVIQDFTKSV MLLQETAILN QENGFHVLKS IELSSALLNR EEKRNKFVYL QVNFGSHHSM
ERVLMVSFHS GYIFVQTDKP IYNPGDTVRF RAFVSSLFFK ALDSSITIDI QNPDGVVVSQ
VSRTRPTQGI YADSFPLSDI VNEGTWLLTA KFDHWQQNAF TSRFEVKKYV LPAFNVTLTP
RKPFLSLDDN ELVVEISARY LFGEPVQGTA YVVFGVKLNQ EMTRLPAVKQ VSDLDGGTVT
LSMQELRRAY PNIRSLVGNS VYVKASVVTK TGSDLVEAEK TGIKIVESPY VLSFKDVPKY
FKPGIPLDLT IQVSQHDGSP ARNVLVKLTH LDAPLTVSSG TARASINMPN VQHPQTLTAE
TAQADLKPEQ QAKQQIRLQP YMTSRGQQNY LYISTGTNRV SVGDRLSLQF SISLSDPSHR
EFIKHITYLV LNKGKIVSAA RQDVTGQLVT SVGLWVTADM MPSFRVVAFF TIPWSGLEEL
VSDSVWIDVV DGCVGGLKVS TDSVQRQYTP GKNFHFQIRG DPGAKVSLVA VDNSVYLLNG
ERLTQKKLWD VVEHGDIGCT RGGGRDAKGV FTDAGLLYFS SGGVKTDTRQ TLQCPGSTRR
RRSAELMQRK ARLESHYKEK LQQRCCKDGL RAIKMPYSCT RRSLYITEGP ECILAFRYCC
ATYRDQVFST EIPTTPPPLT TPPPSTTRPP NTREIVVPYP DFPRVKIISR VWASRESSKV
MRILVESAHI PSPAHIPSPV SDTLEDDEEE EEWEYMDETQ VYLRSKFYES WLWIDVNLPS
ETDRDGFALK NMDSALPDSI TEWGVLAISA SHQTGFCVAE PYNFKTWKHF FVDLKLPYSV
ARYEQLEIKA VIHNYGYDEM HVRVVLMKTE GMCSVAFKDR HTQEVTLPAG SSVAVPYTVV
PLVVGKLPLE VMVVGRDMTG GDRIRKFLRV VMDGVQKTEV WSAVLNPSSQ GGTQTIRVGK
TELESVVPNS VPETFINVRG NVLADSIDNS ISEDSLASLI RMPGGCVEQN LASITLPLIA
TLYLDRTDNW ERVGVDRRDE ALRYIKRGYE NQLEYRRSDG SYPPYRRQGA STWITAYVIK
VFSMAYSIVS MDEQQVCEPL LYLVTNKIIP LSGVYREDNP VYSTTMTGGL RGDDPQITLT
AFVHIAIAEA KKAGISCDRS EVESATAKST QFLKKALQTG GRRPYTVAIA SYALALQGTQ
DNLHQTLLQA ASPDKSHWPD KENHLFTLEA TGYALLALIK LGRLEEAAAP FKWLNGQRRI
GGGFGSTQST MVVLQALSEY MISRPPPADL SLNVDIRMTG RKEIRYYFNP DNAYAARSSK
LPAGIDMEVV AEGNGQGILE VVTHYNQLHE VEEKTPCSHF ELSVNIEESS EKPPADAEKS
YQITINVRSL GPRDVRMVVL DISLPTGFTP ENSDLEMLSN SVDHYISNFK IVDNLSDRGS
LIIHLFKVSH TVPEILIFRL QQTFKVGLLQ PSSVTVYEYY NPDHRCSRTY SPREDREELS
RICDNNVCRC TQGDCCISKP EHQNFLNKER EIFACASLHH VWQVKVLSMN QSYYDKYEME
ITQVIKLGVE AGVEVGQKRF FLSHGGCREG LNLKLGSQYL IIGPKEDQWT TDPGNNKFIY
MLGKDTWVEH WPADAECLSN PSMQAKCKNL SDASNELSAT GCRL
//