ID A0A3B3VPU9_9TELE Unreviewed; 1186 AA.
AC A0A3B3VPU9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Tyrosine kinase non receptor 2 {ECO:0000313|Ensembl:ENSPLAP00000026912.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000026912.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000026912.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B3VPU9; -.
DR Ensembl; ENSPLAT00000019402.1; ENSPLAP00000026912.1; ENSPLAG00000015092.1.
DR GeneTree; ENSGT00940000165248; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd05040; PTKc_Ack_like; 1.
DR CDD; cd09539; SAM_TNK-like; 1.
DR CDD; cd00174; SH3; 1.
DR CDD; cd14274; UBA_ACK1; 1.
DR CDD; cd14328; UBA_TNK1; 1.
DR Gene3D; 4.10.680.10; Cdc42-like binding domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR030220; Ack1_UBA_dom.
DR InterPro; IPR015116; Cdc42-bd-like.
DR InterPro; IPR037085; Cdc42-bd-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR021619; Mig-6.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR049587; TNK-like_SAM.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR015940; UBA.
DR PANTHER; PTHR14254; GENE 33 POLYPEPTIDE; 1.
DR PANTHER; PTHR14254:SF6; NON-SPECIFIC PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF09027; GTPase_binding; 1.
DR Pfam; PF11555; Inhibitor_Mig-6; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR630220-
KW 2}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR630220-2}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..58
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 142..439
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 442..502
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1133..1178
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 562..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..582
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 306
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630220-1"
FT BINDING 148..156
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR630220-2"
FT BINDING 210
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR630220-2"
SQ SEQUENCE 1186 AA; 132101 MW; 159F2C69FD881841 CRC64;
MQCEEGTEWL LELLMEVQLQ QYFKRIRDDL NVTRLSHFDY VKNEDLEKIG MGRPGQRRLW
EAVKRRKAKR KTWMSKVFSG KRIEGEFPQQ GQLASSFRKL SLTPPLCLGD GVLDTQLHGG
SGSSPLDGQQ LALTCLIPEK DLTLFEKLGD GSFGVVKRGE WLTPGGNVVR RRFGSFSPFL
GNEVKFSRQG GGGKKSAINL LILQVNVAVK CLKTDVLSQP DALEDFICEV NAMHSLDHQN
LIRLYGVVLT HPMKMVTELA PLGSLLDRLR CVHPQGPVLI HTLCQYAVQV ASGMAYLEQR
RFIHRDLAAR NILLSSANRV KIGDFGLMRA LPNNDEHYVM QEHRKVPFAW CAPESLKTRT
FSHATDTWMF GVTLWEMFTH GQEPWLGLNG SQILHKIDKE GERLPKPEDC PQDIYNVMLQ
CWAQKPGDRP TFVALREFLL ETMPTDMCAL QDFDELDKLH IKVNDVITII EGRAENYWWR
GQNKRTLKVG QFPRNVVTSV AGLSAHDISR PLKNSFIHTG HGDTNPHRCW GFPDRIDDLY
LGNPMDPPDV LEVDLSAARP TQLPGRTKKE PPPRPPQPAV LIKKPCYDPV TEDEDSTSAV
LRRLSLRKTG SLKGLKLKPA AWVSANKQSS RTSSSAHTPS SDVSLIDFGE DFSPSPVVEN
QNPVLAKLAL QVGNILDKTP PQSPSKWLPR PLHPTPVVDW DARPLPPPPA YDDVAQDEDD
MEVSSITSSE QQLEHDQAAV HGVDGALSSG QMTESDGVVS KDPERPVLED NLFLPGKHNH
AASPSFSQSA EIFQELQQEC MRKLNVPTGG VGQWTQISAS CPTQNTQEDQ QRLSTNEDKP
QIPPRVPIPP RPIKRGDYTS ARWSRDLSVS PMLSDPTYGI SGTTLERPPQ IPPRDPLSQP
NSRTPSPNCA VVGSLHQRIC SVSPSTHQAS HAYSSYLSTS PGKPMPTTHS FASDPKYAAP
KVIQAQDRDN ANRGPCILPI VRDGQKVSNT HYYLLPERPP YLDRFERFFR EAENLPGGGS
AEDRHTRHAN TATVRPMVVT AQTVQGLIQP GELKANFSCN NNFGMSAQRS GMKTSVSLPR
VCSDGLTGPT VNSSCSRTED GGNSLDRVQM VQEAVHGVTI AECQAALQNN SWDVQKAVHY
LKVEQLFCLG LRNRSECIKL LEMCDWNLEQ ASTQILEDYG SITRQR
//
