ID A0A3B3VS30_9TELE Unreviewed; 577 AA.
AC A0A3B3VS30;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2-like {ECO:0000313|Ensembl:ENSPLAP00000027843.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000027843.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000027843.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WFIKKN family.
CC {ECO:0000256|ARBA:ARBA00005743}.
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DR RefSeq; XP_014882154.1; XM_015026668.1.
DR RefSeq; XP_014882278.1; XM_015026792.1.
DR RefSeq; XP_014895498.1; XM_015040012.1.
DR STRING; 48699.ENSPLAP00000012944; -.
DR Ensembl; ENSPLAT00000021206.1; ENSPLAP00000027843.1; ENSPLAG00000016727.1.
DR Ensembl; ENSPLAT00000022754.1; ENSPLAP00000014442.1; ENSPLAG00000018134.1.
DR Ensembl; ENSPLAT00000029776.1; ENSPLAP00000012944.1; ENSPLAG00000016366.1.
DR GeneID; 106943359; -.
DR GeneID; 106943483; -.
DR GeneID; 106952107; -.
DR KEGG; plai:106943359; -.
DR KEGG; plai:106943483; -.
DR KEGG; plai:106952107; -.
DR GeneTree; ENSGT00940000158031; -.
DR OrthoDB; 5298642at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd22606; Kunitz_WFIKKN_2-like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.75.10; Elafin-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR008197; WAP_dom.
DR PANTHER; PTHR45938; ACP24A4-RELATED; 1.
DR PANTHER; PTHR45938:SF7; WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00131; KU; 1.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50189; NTR; 1.
DR PROSITE; PS51390; WAP; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..577
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040590403"
FT DOMAIN 31..84
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 116..167
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 204..298
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 321..377
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 385..435
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 443..566
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 577 AA; 64348 MW; 79542B7D6CC118BA CRC64;
MRWMLFPRWI WFLACASARM ELGGAALPRD TYLHAGICPN EINPNLWVDA MSTCTRECDS
DEECESSEKC CQNVCGNHSC VAARYVDGKK GPVGMPREAS CASFMCTQQG SECVIWEGRP
LCKCRDRCEK EPNFTCASDG MTYYNKCFMD AEACSKGITL SVVMCRFHLT WPNMSPLLPQ
LTTLRPTTAP FQPTVPLPLE PEQPVLVTSP IHQTVNVGET ASFLCDVTGQ PQPQIMWEKR
LPLGDVRVIM RPNNVLGNMV VTNIGQLVIY NTRLQDSGVY TCIAQNPSGS VQVHHPLTVL
SAEVFSTLGP KNLTRCLPEE CQNPFDSPED CGTGLEKVSW YYEPKSNNCF PFRHCHSSND
QSPRKMFDTY EGCIQCCGPE VSRPCGLPAL QGRCKVYEPR WAYISTMGKC QSFIYGGCEG
NDNNFESKQL CEEMCPFPKN HHCKACKPRG KMVTSFCRSD FVVLGRMTDI TQENDSGHAL
VTVEEIFKDE KMGLRFFGKE PLEVTFLNMD WNCPCPNITG AAAEGQVIIM GNVSEGMAIL
QPESYVGAST PRRVRKLKEV ISKNTCNILK AITNSPQ
//
