ID   A0A3B3VT97_9TELE        Unreviewed;       490 AA.
AC   A0A3B3VT97;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Protein Mdmx {ECO:0000256|ARBA:ARBA00044325};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000028092.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000028092.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MDM2/MDM4 family.
CC       {ECO:0000256|ARBA:ARBA00005803, ECO:0000256|PIRNR:PIRNR006748}.
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DR   RefSeq; XP_014892212.1; XM_015036726.1.
DR   AlphaFoldDB; A0A3B3VT97; -.
DR   STRING; 48699.ENSPLAP00000028092; -.
DR   Ensembl; ENSPLAT00000021713.1; ENSPLAP00000028092.1; ENSPLAG00000017184.1.
DR   GeneID; 106950076; -.
DR   CTD; 4194; -.
DR   GeneTree; ENSGT00530000063539; -.
DR   OrthoDB; 2916169at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   CDD; cd17673; MDM4; 1.
DR   CDD; cd16784; mRING-HC-C2H2C4_MDM4; 1.
DR   Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR   InterPro; IPR016495; p53_neg-reg_MDM_2/4.
DR   InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR   InterPro; IPR003121; SWIB_MDM2_domain.
DR   InterPro; IPR001876; Znf_RanBP2.
DR   InterPro; IPR036443; Znf_RanBP2_sf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12183; MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1; 1.
DR   PANTHER; PTHR12183:SF37; PROTEIN MDM4; 1.
DR   Pfam; PF02201; SWIB; 1.
DR   Pfam; PF00641; zf-RanBP; 1.
DR   PIRSF; PIRSF006748; p53_MDM_2/4; 1.
DR   SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR   SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR   PROSITE; PS51925; SWIB_MDM2; 1.
DR   PROSITE; PS01358; ZF_RANBP2_1; 1.
DR   PROSITE; PS50199; ZF_RANBP2_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR006748};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR006748};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00322}.
FT   DOMAIN          23..106
FT                   /note="DM2"
FT                   /evidence="ECO:0000259|PROSITE:PS51925"
FT   DOMAIN          300..329
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  54229 MW;  C4C59B414525CBBC CRC64;
     MSSLSAQPQA SSSSCRTLPG EGNQVKPKAP LLQILRVAGA QEDVFTLKEV MHYLGQYIMG
     KQLYDKQRQH IVHCQDDPLG ELLEVESFSV KNPSPVYEML KKYLIVLGCS DAAENLSVGR
     ECVEGGVEDR GQICEGVVKA GVVAGNDGPL LPTPSQRRPR DPDDESLEGL PRSACKRPKL
     DVTLEEWDLS GLPWWFLGNL RNNYSRRSNG STDIHTNQEE DTAIVSDTTE DLWILTEGES
     EQVSVEMKEA ALEEGSGGEE GSVDDDYGGG KEEKSDREMQ EEPDEDSQCL SDDTDTEIST
     QDAWQCTECR KYNIPVQRYC VRCWALRKNW YKDVPRLAHS LSVPDIPACS SLSAHDEEDD
     SDTGIDVPDC SRTVSDPVIL PSHSTADRPI PTAGMSRGKG PRPSGFHKHG QLSEGESQES
     LGMEVQDIRP EALLEPCKLC RVRPRNGNII HGRTAHLLTC FPCARRLHKF QAPCPGCGKI
     IQKVIKIFIL
//